Publication Name	World Journal of Psychiatry
Manuscript ID	126586
DOI	10.5498/wjp.126586
Country	China

Category	Psychology, Clinical
Manuscript Type	Observational Study
Article Title	Association of cerebral tissue oxygenation status and systemic inflammatory markers with delirium in mechanically ventilated intensive care unit patients
Manuscript Source	Unsolicited Manuscript
All Author List	Pei-Pei Liang and Min Yang
Funding Agency and Grant Number
Corresponding Author	Min Yang, MD, The Second Department of Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, No. 678 Furong Road, Economic and Technological Development Zon, Hefei 230601, Anhui Province, China. yfy1531254@fy.ahmu.edu.cn
Key Words	Mechanical ventilation; Emergency intensive care unit; Delirium; regional cerebral oxygen saturation; Systemic inflammatory markers; Neutrophil-to-lymphocyte ratio
Core Tip	In mechanically ventilated emergency intensive care unit (ICU) patients, 31 of 80 patients (38.75%) developed incident delirium after the predefined baseline window. The delirium group had lower regional cerebral oxygen saturation (rSO2) and higher neutrophil-to-lymphocyte ratio (NLR). In the parsimonious adjusted analysis, lower rSO2 and higher NLR remained associated with incident delirium, whereas total mechanical-ventilation duration was treated as a post-baseline clinical-course variable rather than an antecedent predictor. These findings are hypothesis-generating and may provide adjunctive bedside information, but rSO2 and NLR should not replace standardized delirium assessment with Confusion Assessment Method for the ICU.
Citation	Liang PP, Yang M. Association of cerebral tissue oxygenation status and systemic inflammatory markers with delirium in mechanically ventilated intensive care unit patients. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.126586
PDF	126586-in-press.pdf

Received	2026-08-07 12:07
Peer-Review Started	2026-08-07 12:07
First Decision by Editorial Office Director
Return for Revision	2026-08-31 01:41
Revised	2026-09-10 01:38
Publication Fee Transferred	2026-09-29 09:08
Second Decision by Editor	2026-11-02 02:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-02 03:23
Articles in Press	2026-11-02 03:23
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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