Publication Name	World Journal of Clinical Oncology
Manuscript ID	126647
Country	China

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Characterization of the cellular and transcriptomic landscapes of natural killer cells in hematopoietic microenvironment of myelodysplastic syndrome
Manuscript Source	Invited Manuscript
All Author List	Su-Yun Liu, Xiu-Mei Feng, Zi-Ying Chen, Zhi-Qiang Chen, Yu-Ru Shang, Michael Linnebacher, Yuan-Xin Wang, Shan-Shan Zhang, Min Cai and Lei-Sheng Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Shandong Province ZR2025MS1382 Taishan Scholar Special Funding of Shandong Province Funding tsqnz20240858 Science and Technology Development Plan of Jinan Municipal Health Commission 2025202005 Medical and Health Technology Project of Shandong Province 202402050122 Clinical Medical Science and Technology Innovation Program of Jinan Science and Technology Bureau 202430055
Corresponding Author	Lei-Sheng Zhang, Director, PhD, Professor, Senior Researcher, Shandong Provincial Key Medical and Health Laboratory of Blood Ecology and Biointelligence, Jinan Key Laboratory of Medical Cell Bioengineering, Science and Technology Innovation Center, The Fourth People’s Hospital of Jinan Affiliated to Shandong Second Medical University, No. 50 Shifan Road, Tianqiao District, Jinan 250031, Shandong Province, China. kczxzls@jn.shandong.cn
Key Words	Myelodysplastic syndrome; Natural killer cells; Bone marrow blood; Cell viability; Transcriptomic signatures
Core Tip	Myelodysplastic syndrome (MDS) are myeloid malignancies of hematopoietic stem cells with limited treatment options. Longitudinal studies have highlighted the tumor microenvironment and dysregulated immune response in MDS, yet the pathogenesis of natural killer cells (NKs) are largely obscure. Therewith, we dissected the biological and transcriptomic signatures of NKs in bone marrow of MDS patients, which would facilitate the further exploration of MDS-NK-meditated pathogenesis and treatment options in future.
Citation	Liu SY, Feng XM, Chen ZY, Chen ZQ, Shang YR, Linnebacher M, Wang YX, Zhang SS, Cai M, Zhang LS. Characterization of the cellular and transcriptomic landscapes of natural killer cells in hematopoietic microenvironment of myelodysplastic syndrome. World J Clin Oncol 2026; In press

Received	2026-08-11 03:45
Peer-Review Started	2026-08-11 03:46
First Decision by Editorial Office Director
Return for Revision	2026-09-03 06:54
Revised	2026-09-06 05:38
Publication Fee Transferred
Second Decision by Editor	2026-10-08 07:09
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-08 08:36
Articles in Press	2026-10-08 08:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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