Publication Name	World Journal of Experimental Medicine
Manuscript ID	126679
Country	Malaysia

Category	Dentistry, Oral Surgery & Medicine
Manuscript Type	Observational Study
Article Title	Periodontal status and systemic interleukin-6 levels in stroke patients: A cross-sectional study
Manuscript Source	Invited Manuscript
All Author List	Hanim Afzan Ibrahim, Nur Najla Qistina Kharul Nizam, Harishini Rajaratinam, Muhammad Hafiz Hanafi, Haslina Taib, Rabiatul Adawiyah Mohamad Noor and Nur Karyatee Kassim
Funding Agency and Grant Number	Funding Agency Grant Number Fundamental Research Grant Scheme (FRGS), Ministry of Education, Malaysia. FRGS/1/2023/SKK10/USM/02/5
Corresponding Author	Nur Karyatee Kassim, Associate Professor, Medical and Basic Dental Sciences Unit, School of Dental Sciences, Universiti Sains Malaysia, Jalan Raja Perempuan Zainab II, Kota Bharu 16150, Kelantan, Malaysia. karyatee@usm.my
Key Words	Inflammatory marker; Interleukin-6; Oral health; Periodontitis; Stroke
Core Tip	This study highlights the association between stroke and periodontal disease by comparing periodontal status and serum interleukin-6 (IL-6) levels between stroke and non-stroke participants. Periodontitis was markedly more prevalent among stroke patients, who also demonstrated poorer periodontal parameters. Despite the established inflammatory roles of IL-6 in both conditions, serum IL-6 levels did not differ significantly between groups and were not associated with periodontal severity. These findings reinforce the importance of periodontal assessment in stroke patients while suggesting that circulating IL-6 alone may not adequately reflect the inflammatory relationship between periodontitis and stroke. Further studies should investigate other potential inflammatory mediators.
Citation	Ibrahim HA, Kharul Nizam NNQ, Rajaratinam H, Hanafi MH, Taib H, Mohamad Noor RA, Kassim NK. Periodontal status and systemic interleukin-6 levels in stroke patients: A cross-sectional study. World J Exp Med 2026; In press

Received	2026-08-17 09:15
Peer-Review Started	2026-08-17 09:16
First Decision by Editorial Office Director
Return for Revision	2026-08-28 06:45
Revised	2026-09-25 13:45
Publication Fee Transferred
Second Decision by Editor	2026-11-10 03:08
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-10 10:29
Articles in Press	2026-11-10 10:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com