Publication Name	World Journal of Gastroenterology
Manuscript ID	126681
DOI	10.3748/wjg.126681
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Circadian disruption in metabolic dysfunction-associated steatotic liver disease: From hepatic clock remodeling to chronotherapeutic strategies
Manuscript Source	Invited Manuscript
All Author List	Zi-Qiang Duan, Hai-Xia Wang, Chang-Hui Sun, Rui-Ming Wen and Hong-Bin Yu
Funding Agency and Grant Number
Corresponding Author	Rui-Ming Wen, Professor, School of Physical Education and Sports Science, South China Normal University, No. 378 Outer Ring West Road, Guangzhou 510006, Guangdong Province, China. wenruiming@m.scnu.edu.cn
Key Words	Metabolic dysfunction-associated steatotic liver disease; Liver metabolism; Circadian rhythm; Hepatic clock remodeling; Chronotherapy
Core Tip	Circadian disruption may represent a temporal regulatory dimension rather than a secondary consequence of metabolic dysfunction-associated steatotic liver disease. This review defines hepatic clock remodeling as multidimensional alterations in phase, amplitude, period, cellular synchronization, and clock-controlled metabolic outputs. It integrates time-resolved human evidence with cell- and tissue-specific experimental studies, distinguishes clinically supported interventions from preclinical strategies, and identifies priorities for chronobiology-informed trials and personalized treatment.
Citation	Duan ZQ, Wang HX, Sun CH, Wen RW, Yu HB. Circadian disruption in metabolic dysfunction-associated steatotic liver disease: From hepatic clock remodeling to chronotherapeutic strategies. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.126681
PDF	126681-in-press.pdf

Received	2026-08-11 03:45
Peer-Review Started	2026-08-11 03:46
First Decision by Editorial Office Director
Return for Revision	2026-09-03 06:30
Revised	2026-09-04 12:49
Publication Fee Transferred
Second Decision by Editor	2026-10-26 07:15
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-26 09:52
Articles in Press	2026-10-26 09:52
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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