Publication Name	World Journal of Clinical Cases
Manuscript ID	126695
DOI	10.12998/wjcc.126695
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Precision stratification for hepatitis B functional cure: Biomarkers, machine learning and the combination-therapy era
Manuscript Source	Invited Manuscript
All Author List	Ahmed Salman
Funding Agency and Grant Number
Corresponding Author	Ahmed Salman, FRACP, FRCP, Department of Internal Medicine, Kasr Alainy School of Medicine, 1 Al-Saray Street, Al-Manial, Cairo 11559, Al Qāhirah, Egypt. awea844@gmail.com
Key Words	Hepatitis B virus; Functional cure; Hepatitis B surface antigen; Biomarkers; Machine learning; Hepatocellular carcinoma
Core Tip	A low baseline hepatitis B surface antigen level is associated with response to several investigational regimens, but it should not be treated as a universal treatment-selection threshold. This minireview distinguishes functional cure from other antigen endpoints, separates baseline selection from on-treatment prediction, and appraises model validation, safety, and external validity. No integrated model is available for allocating curative regimens. Hepatocellular carcinoma risk persists after antigen loss; current guideline-based surveillance should continue where indicated, whereas prospective studies should evaluate risk-based refinement.
Citation	Salman A. Precision stratification for hepatitis B functional cure: Biomarkers, machine learning and the combination-therapy era. World J Clin Cases 2026; In press DOI: https://doi.org/10.12998/wjcc.126695
PDF	126695-in-press.pdf

Received	2026-08-11 03:46
Peer-Review Started	2026-08-11 03:46
First Decision by Editorial Office Director
Return for Revision	2026-09-14 07:35
Revised	2026-09-22 09:18
Publication Fee Transferred
Second Decision by Editor	2026-10-09 03:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-09 09:10
Articles in Press	2026-10-09 09:10
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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