Publication Name	World Journal of Nephrology
Manuscript ID	126698
DOI	10.5527/wjn.126698
Country	Egypt

Category	Urology & Nephrology
Manuscript Type	Systematic Reviews
Article Title	Renal and cardiovascular effects of glucagon-like peptide receptor agonists in established chronic kidney disease: Systematic review and meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Kirolos Eskandar, Kirolos I Attiya, Hassan A Abdou and Peter M Seffen
Funding Agency and Grant Number
Corresponding Author	Kirolos Eskandar, MD, Researcher, Department of Medicine and Surgery, Helwan University, Giza 11795, Al Jīzah, Egypt. kirolos210575@med.capu.edu.eg
Key Words	Chronic kidney disease; Glucagon-like peptide receptor agonists; Renal outcomes; Estimated glomerular filtration rate; Albuminuria; Cardiovascular outcomes
Core Tip	This systematic review and meta-analysis applied a restrictive chronic kidney disease (CKD)-specific framework to randomized evidence, requiring each analyzed population to meet predefined CKD criteria and explicitly accounting for overlap among publications from the same parent trial. Thirteen publications were eligible, but only three independent parent populations informed the two primary meta-analyses. Glucagon-like peptide-1 receptor agonists showed a numerically favorable but statistically nonsignificant association with the composite kidney outcome, while annual estimated glomerular filtration rate slope was also nonsignificant. Other renal and cardiovascular outcomes could not be pooled because comparable independent CKD-specific estimates were unavailable. The findings emphasize the limited precision of the current evidence base.
Citation	Eskandar K, Attiya KI, Abdou HA, Seffen PM. Renal and cardiovascular effects of glucagon-like peptide receptor agonists in established chronic kidney disease: Systematic review and meta-analysis. World J Nephrol 2026; In press DOI: https://doi.org/10.5527/wjn.126698
PDF	126698-in-press.pdf

Received	2026-08-11 02:47
Peer-Review Started	2026-08-13 05:59
First Decision by Editorial Office Director
Return for Revision	2026-08-21 09:42
Revised	2026-08-21 17:11
Publication Fee Transferred
Second Decision by Editor	2026-10-09 03:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-09 09:53
Articles in Press	2026-10-09 09:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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