Publication Name	World Journal of Clinical Oncology
Manuscript ID	126700
DOI	10.5306/wjco.126700
Country	Italy

Category	Surgery
Manuscript Type	Minireviews
Article Title	Specific molecular signature redefines the role of posterior and para-aortic (D2 plus) lymphadenectomy in gastric cancer: Rethinking surgical indications
Manuscript Source	Invited Manuscript
All Author List	Ludovico Carbone, Daniele Marrelli, Bina Barbato, Aurora Visani, Giovanni Corso and Franco Roviello
Funding Agency and Grant Number
Corresponding Author	Daniele Marrelli, MD, Department of Medicine Surgery and Neuroscience, University of Siena, viale Mario Bracci 11, Siena 53100, Tuscany, Italy. daniele.marrelli@unisi.it
Key Words	Stomach cancer; Multimodality approach; Lymph node excision; Translational research; Mismatch repair deficiency; Complications; Robot surgery
Core Tip	D2 plus lymphadenectomy in gastric cancer should be tailored to tumor biology and treatment response. Pathological response to neoadjuvant therapy is the strongest prognostic factor, whereas the emerging molecular characterization (microsatellite instable, programmed cell death ligand 1, epithelial-mesenchymal transition, or human epidermal growth factor receptor 2 status) predicts nodal spread pattern and tumors which likely benefit from extended nodal dissection. In selected oligometastatic patients, para-aortic lymphadenectomy can be integrated into a conversion surgery strategy to achieve complete radicality. Molecular profiling, therefore, represents a promising tool to refine treatment course and surgical indications for lymphadenectomy beyond tumor node metastasis staging alone.
Citation	Carbone L, Marrelli D, Barbato B, Visani A, Corso G, Roviello F. Specific molecular signature redefines the role of posterior and para-aortic (D2 plus) lymphadenectomy in gastric cancer: Rethinking surgical indications. World J Clin Oncol 2026; In press DOI: https://doi.org/10.5306/wjco.126700
PDF	126700-in-press.pdf

Received	2026-08-11 03:05
Peer-Review Started	2026-08-11 03:06
First Decision by Editorial Office Director
Return for Revision	2026-08-24 03:08
Revised	2026-08-28 16:59
Publication Fee Transferred
Second Decision by Editor	2026-11-02 02:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-02 02:44
Articles in Press	2026-11-02 02:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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