Publication Name	World Journal of Clinical Cases
Manuscript ID	126744
DOI	10.12998/wjcc.126744
Country	Brazil

Category	Transplantation
Manuscript Type	Case Report
Article Title	Acute liver failure temporally associated with intensive consumption of Plantago major tea: A case report
Manuscript Source	Invited Manuscript
All Author List	Raul V Ponte, Anderson A Faria, Ludmila R Guedes, Isabela S Yamashiro, Maria L Macedo, Maria C Lima, Priscila F Souza, Paula V Vidigal, Francisco G Penna and João B Sancio
Funding Agency and Grant Number
Corresponding Author	Raul V Ponte, MD, Department of Abdominal Transplant Surgery, Fortaleza General Hospital, 900 Riachuelo St, Fortaleza 60822265, Ceara, Brazil. rppp@live.com
Key Words	Plantago major; Herb-induced liver injury; Acute liver failure; Liver transplantation; Case report
Core Tip	This case describes acute liver failure temporally associated with intensive consumption of Plantago major tea in a previously healthy 44-year-old woman. After consuming approximately 2 L/day of prepared infusion for 15 consecutive days, she developed progressive hepatic dysfunction and grade III hepatic encephalopathy, ultimately requiring urgent liver transplantation. Explant histology demonstrated nonspecific massive hepatic necrosis and marked cholestasis. Although the temporal relationship raises suspicion for herb-induced liver injury, causality cannot be definitively established because the herbal preparation was not botanically authenticated or chemically analyzed.
Citation	Ponte RV, Faria AA, Guedes LR, Yamashiro IS, Macedo ML, Lima MC, Souza PF, Vidigal PV, Penna FG, Sancio JB. Acute liver failure temporally associated with intensive consumption of Plantago major tea: A case report. World J Clin Cases 2026; In press DOI: https://doi.org/10.12998/wjcc.126744
PDF	126744-in-press.pdf

Received	2026-08-13 06:50
Peer-Review Started	2026-08-13 06:51
First Decision by Editorial Office Director
Return for Revision	2026-08-25 06:22
Revised	2026-09-07 19:43
Publication Fee Transferred
Second Decision by Editor	2026-09-16 07:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-16 09:48
Articles in Press	2026-09-16 09:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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