Publication Name	World Journal of Cardiology
Manuscript ID	126752
DOI	10.4330/wjc.126752
Country	Jordan

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Observational Study
Article Title	Role of novel inflammatory indices in predicting major adverse cardiovascular events following revascularization in chronic limb-threatening ischemia
Manuscript Source	Invited Manuscript
All Author List	Abeer A Alwahadneh, Jafar A Alshraideh, Dania A Bani Hani, Mohammad S Abdallah, Kawther Al-Hadidi, Bayan Alshraideh and Khalil Yousef
Funding Agency and Grant Number
Corresponding Author	Jafar A Alshraideh, PhD, Professor, Clinical Nursing, The University of Jordan, Amman, Jordan, The University of Jordan, Amman 11942 Jordan, Amman 11942, --- Select One ---, Jordan. jalasad@ju.edu.jo
Key Words	Peripheral artery disease; Chronic limb-threatening ischemia; Inflammatory indices; Major adverse cardiovascular events; Revascularization
Core Tip	In this prospective multicenter cohort of patients with chronic limb-threatening ischemia undergoing lower-limb revascularization, Systemic Inflammatory Response Index (SIRI) was independently associated with six-month major adverse cardiovascular events and improved the discriminatory performance of a multivariable clinical model. Bootstrap internal validation demonstrated that the model retained strong discriminatory ability after correction for optimism. These findings highlight the potential of SIRI to refine cardiovascular risk assessment in this high-risk population, while external validation in independent cohorts remains essential before clinical implementation.
Citation	Alwahadneh AA, Alshraideh JA, Hani DAB, Abdallah MS, Al-Hadidi K, Alshraideh B, Yousef K. Role of novel inflammatory indices in predicting major adverse cardiovascular events following revascularization in chronic limb-threatening ischemia. World J Cardiol 2026; In press DOI: https://doi.org/10.4330/wjc.126752
PDF	126752-in-press.pdf

Received	2026-08-12 06:59
Peer-Review Started	2026-08-12 07:00
First Decision by Editorial Office Director
Return for Revision	2026-08-20 07:11
Revised	2026-09-01 11:48
Publication Fee Transferred
Second Decision by Editor	2026-10-26 07:15
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-26 10:16
Articles in Press	2026-10-26 10:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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