Publication Name	World Journal of Gastroenterology
Manuscript ID	126797
DOI	10.3748/wjg.126797
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Weiduqing formula alleviates gastric precancerous lesions in association with autophagy-related protein 5-dependent autophagy
Manuscript Source	Unsolicited Manuscript
All Author List	Ling-Chen Liao, Lai-Feng Wu, Yi-Fei Wang, Xue-Yi Chen, Jian-Hui Gu, Zi-Wei Xia, Gang Fang, Yu-Zhou Pang and Zhi-Yong Cao
Funding Agency and Grant Number	Funding Agency Grant Number National Administration of Traditional Chinese Medicine High-Level Key Discipline Construction Project of Traditional Chinese Medicine/Ethnic Minority Medicine (Zhuang Medicine) No. zyyzdxk-2023164 Guangxi University of Chinese Medicine University-level Research Project No. 2025QN014 Guangxi Young Elite Scientist Sponsorship Program No. GXYESS2025186
Corresponding Author	Zhi-Yong Cao, Institute of Traditional Chinese and Zhuang-Yao Ethnic Medicine, Guangxi University of Chinese Medicine, No. 179 Mingxiu East Road, Xixiang Tang District, Nanning 530200, Guangxi Zhuang Autonomous Region, China. caozhiyong2019@163.com
Key Words	Weiduqing formula; Gastric precancerous lesions; Autophagy; Stearoyl-CoA desaturase 1; Metabolomics; Microbiota
Core Tip	This study evaluated the protective effects and mechanism of Weiduqing formula in gastric precancerous lesions. In rat and gastric epithelial cell models induced by N-methyl-N’-nitro-N-nitrosoguanidine, treatment reduced mucosal atrophy, intestinal metaplasia, inflammation, and malignant phenotypic changes. Integrated serum pharmacochemistry, metabolomics, proteomics, and network pharmacology prioritized stearoyl-CoA desaturase 1 (SCD1) as a treatment-responsive mediator. Functional experiments showed restored autophagic flux and an autophagy-related protein 5-dependent increase in SCD1-p62 co-localization. Weiduqing formula also partially remodeled gastric microbial composition. These findings identify a candidate mechanism and support further translational study.
Citation	Liao LC, Wu LF, Wang YF, Chen XY, Gu JH, Xia ZW, Fang G, Pang YZ, Cao ZY. Weiduqing formula alleviates gastric precancerous lesions in association with autophagy-related protein 5-dependent autophagy. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.126797
PDF	126797-in-press.pdf

Received	2026-08-19 03:07
Peer-Review Started	2026-08-19 03:07
First Decision by Editorial Office Director
Return for Revision	2026-09-02 10:43
Revised	2026-09-15 06:45
Publication Fee Transferred	2026-09-22 09:18
Second Decision by Editor	2026-11-02 02:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-04 10:47
Articles in Press	2026-11-04 10:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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