Publication Name	World Journal of Critical Care Medicine
Manuscript ID	127114
DOI	10.5492/wjccm.127114
Country	India

Category	Critical Care Medicine
Manuscript Type	Case Control Study
Article Title	Bedside ultrasonographic optic nerve sheath diameter for detecting raised intracranial pressure in children with acute encephalitis syndrome
Manuscript Source	Unsolicited Manuscript
All Author List	Sakshi Singh, Sciddhartha Koonwar, Suhail S Siddiqui, Shally Awasthi, Shivang Jha, Prabhaker Mishra and Anit Parihar
Funding Agency and Grant Number
Corresponding Author	Sakshi Singh, Assistant Professor, Department of Pediatrics, King George's Medical University, Shah Mina Road, Lucknow 226001, Uttar Pradesh, India. sakshi.singh.kgmu@gmail.com
Key Words	Acute encephalitis syndrome; Case-control study; Intracranial pressure; Optic nerve sheath diameter; Ocular ultrasonography; Pediatric intensive care; Diagnostic accuracy
Core Tip	In this prospective case-control study of 82 children [41 with acute encephalitis syndrome (AES) and 41 controls], bedside ultrasonographic optic nerve sheath diameter (ONSD) differed significantly across children with computed tomography (CT) features suggestive of raised intracranial pressure (ICP), those without such features, and controls. Average bilateral ONSD showed moderate discriminatory ability (area under the curve 0.766) for CT features suggestive of raised ICP, with a cut-off of 5.74 mm providing 82.4% sensitivity and 62.5% specificity, and a lower threshold of 5.47 mm providing 100% sensitivity [95% confidence interval (CI): 80.5-100] and 100% negative predictive value (95%CI: 75.3-100); given that only 17 children were CT-positive, these thresholds should be regarded as exploratory. Bedside ONSD ultrasonography may help identify children with AES who warrant closer evaluation for possible intracranial hypertension, particularly where immediate neuroimaging or invasive ICP monitoring is not readily available, though it should be interpreted as part of a multimodal assessment rather than as a stand-alone substitute for direct ICP monitoring.
Citation	Singh S, Koonwar S, Siddiqui SS, Awasthi S, Jha S, Mishra P, Parihar A. Bedside ultrasonographic optic nerve sheath diameter for detecting raised intracranial pressure in children with acute encephalitis syndrome. World J Crit Care Med 2026; In press DOI: https://doi.org/10.5492/wjccm.127114
PDF	127114-in-press.pdf

Received	2026-08-24 07:30
Peer-Review Started	2026-08-24 07:30
First Decision by Editorial Office Director
Return for Revision	2026-09-15 03:35
Revised	2026-09-27 20:03
Publication Fee Transferred	2026-10-08 16:02
Second Decision by Editor	2026-11-05 02:11
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-05 09:08
Articles in Press	2026-11-05 09:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com