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Articles in Press
10/28/2026 10:43:40 AM | Browse: 30 | Download: 7
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Immunosenescence and microbial ecology in gastrointestinal and hepatobiliary infection-associated cancers
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Wen-Ge Li and Xin Yu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fujian Provincial Health Commission |
2025-S-wq14 |
| Natural Science Foundation of Fujian Province |
2026J001185 |
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| Corresponding Author |
Wen-Ge Li, MD, Department of Oncology, Fuzhou Pulmonary Hospital of Fujian, No. 8 Beiyuan Road, Cangshan District, Fuzhou 350008, Fujian Province, China. 2012302180081@whu.edu.cn |
| Key Words |
Immunosenescence; Microbiota; Helicobacter pylori; Gastric neoplasms; Hepatocellular carcinoma; Cholangiocarcinoma; Viral hepatitis; Infection-associated cancer |
| Core Tip |
This review integrates immunosenescence and compartment-specific microbial ecology within the context of gastrointestinal and hepatobiliary infection-associated cancers. We distinguish immunosenescence from T-cell exhaustion and cellular senescence, and compare evidence across Helicobacter pylori-associated gastric cancer, hepatitis B/C virus-associated hepatocellular carcinoma, and liver-fluke-associated cholangiocarcinoma, with colorectal cancer as a mechanistic comparator. Particular attention is given to anatomical compartment, evidence directness, disease stage, and reversibility after pathogen control. Current evidence supports several mechanistic links, but a complete microbiota–immune aging–cancer causal sequence in humans remains unproven. These considerations support a pathogen-first approach to clinical translation and highlight priorities for longitudinal, compartment-matched studies. |
| Citation |
Li WG, Yu X. Immunosenescence and microbial ecology in gastrointestinal and hepatobiliary infection-associated cancers. World J Gastroenterol 2026; In press
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| PDF |
127135-in-press.pdf
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Received |
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2026-08-24 11:00 |
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Peer-Review Started |
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2026-08-24 11:01 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-09-07 08:11 |
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Revised |
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2026-09-19 02:51 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-10-28 07:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-28 10:43 |
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Articles in Press |
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2026-10-28 10:43 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
