Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	127166
DOI	10.4251/wjgo.127166
Country	Ireland

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Sporadic diffuse gastric cancer in Western populations and the mismatch between tumour biology and clinical care
Manuscript Source	Invited Manuscript
All Author List	Eoghan Burke
Funding Agency and Grant Number
Corresponding Author	Eoghan Burke, Consultant, FRCS (Gen Surg), Principal Investigator, Researcher, Department of upper Gastrointestinal Surgery, Beaumont Hospital, Beaumont Hospital, Dublin, Ireland, Dublin 12345, Ireland. eoghanburke@rcsi.ie
Key Words	Diffuse-type gastric cancer; Poorly cohesive carcinoma; Gastric carcinogenesis; Gastric atrophy; Molecular biomarkers; Systemic therapy; Immunotherapy; Peritoneal metastasis; Staging laparoscopy
Core Tip	VPopulation growth and ageing may increase Western gastric cancer case numbers, while historical registry data suggest a changing relative contribution of diffuse disease. Sporadic diffuse cancer lacks a validated precursor and can evade diagnosis. Its enrichment for genomically stable biology, lower human epidermal growth factor receptor 2 positivity and less frequent mismatch-repair deficiency complicate systemic-treatment selection, while programmed death-ligand 1 expression remains variable. Histological subgroup analyses incompletely define treatment benefit, making individual biomarker testing and better therapeutic evidence essential. Peritoneal tropism adds a further challenge, requiring regional chemotherapy and surgery to be tested separately alongside systemic care. These connected gaps demand a subtype-specific response to the changing burden.
Citation	Burke E. Sporadic diffuse gastric cancer in Western populations and the mismatch between tumour biology and clinical care. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.127166
PDF	127166-in-press.pdf

Received	2026-08-24 11:00
Peer-Review Started	2026-08-24 11:00
First Decision by Editorial Office Director
Return for Revision	2026-09-10 12:37
Revised	2026-09-13 13:33
Publication Fee Transferred
Second Decision by Editor	2026-10-09 03:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-09 09:30
Articles in Press	2026-10-09 09:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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