Publication Name	World Journal of Stem Cells
Manuscript ID	127214
DOI	10.4252/wjsc.127214
Country	China

Category	Engineering, Biomedical
Manuscript Type	Minireviews
Article Title	Potential roles of bacterial extracellular vesicles in mesenchymal stem/stromal cell-mediated bone repair
Manuscript Source	Invited Manuscript
All Author List	Tong-Han Zhao and Jin Shao
Funding Agency and Grant Number	Funding Agency Grant Number Three-Voyage Talent Development Program at Pudong Gongli Hospital, Shanghai University of Medicine & Health Sciences 2026-GLSHLH-01 University of Shanghai for Science and Technology Medical Engineering Cross Fund 2023CH-GL11Z Cultivation Fund for the National Natural Science Foundation of China 2024GPY-A05
Corresponding Author	Jin Shao, Associate Professor, Deputy Director, MD, PhD, Department of Orthopedics, Pudong Gongli Hospital, Shanghai University of Medicine & Health Sciences, No. 219 Miaopu Road, Pudong New Area, Shanghai 200135, China. sj01313@glhospital.com
Key Words	Bacterial extracellular vesicles; Mesenchymal stem cells; Bone regeneration; Osteoimmunology; Osteogenesis; Drug delivery systems
Core Tip	Bacterial extracellular vesicles (BEVs) provide a framework for understanding how microbial signals influence mesenchymal stem/stromal cell (MSC)-mediated bone repair. Available evidence comprises direct effects on MSCs/bone marrow-derived MSCs, supportive evidence from other osteogenic-lineage cells, and indirect effects mediated by macrophages, osteoclasts, and endothelial cells. These actions depend on vesicle source, cargo, dose, target-cell state, and disease context. Increases in bone mass or reductions in bone resorption should not be equated with demonstrated fracture or bone-defect regeneration. Defining these evidence boundaries and developing controllable engineered BEVs are essential for translation.
Citation	Zhao TH, Shao J. Potential roles of bacterial extracellular vesicles in mesenchymal stem/stromal cell-mediated bone repair. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.127214
PDF	127214-in-press.pdf

Received	2026-08-26 06:36
Peer-Review Started	2026-08-26 06:36
First Decision by Editorial Office Director
Return for Revision	2026-09-15 03:15
Revised	2026-09-28 09:43
Publication Fee Transferred
Second Decision by Editor	2026-10-30 09:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-06 10:31
Articles in Press	2026-11-06 10:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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