Publication Name	World Journal of Translational Medicine
Manuscript ID	127250
DOI	10.5528/wjtm.127250
Country	Spain

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Iron, inflammation, and fibroblast growth factor 23: Integrating molecular crosstalk, cardiovascular biology, and therapeutic perspectives
Manuscript Source	Invited Manuscript
All Author List	Javier Donate-Correa
Funding Agency and Grant Number	Funding Agency Grant Number Fundación Canaria Instituto de Investigación Sanitaria de Canarias No. PIFIISC25/02 and No. PIFIISC24/12 Instituto de Salud Carlos III No. PI21/00337 and No. PI24/02183 Fundación MAPFRE Canarias No. OA25/121
Corresponding Author	Javier Donate-Correa, PhD, Principal Investigator, Unidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, Carretera del Rosario 145, Santa Cruz de Tenerife 38010, Spain. jdonatecorrea@gmail.com
Key Words	Fibroblast growth factor 23; Iron deficiency; Inflammation; Hepcidin; Erythropoiesis; Cardiovascular disease; Chronic kidney disease; Hypophosphatemia
Core Tip	Distinguishing fibroblast growth factor 23 production from proteolytic processing explains discordant intact and C-terminal assay results and formulation-specific effects of intravenous iron on phosphate. Experimental cardiac, inflammatory, and erythroid mechanisms require validation in humans. Therapeutic studies should test causality while preserving phosphate homeostasis, because global hormone neutralization caused harm in experimental chronic kidney disease.
Citation	Donate-Correa J. Iron, inflammation, and fibroblast growth factor 23: Integrating molecular crosstalk, cardiovascular biology, and therapeutic perspectives. World J Transl Med 2026; In press DOI: https://doi.org/10.5528/wjtm.127250
PDF	127250-in-press.pdf

Received	2026-08-25 03:33
Peer-Review Started	2026-08-25 03:34
First Decision by Editorial Office Director
Return for Revision	2026-09-15 07:50
Revised	2026-09-17 15:57
Publication Fee Transferred
Second Decision by Editor	2026-10-22 03:01
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-22 09:18
Articles in Press	2026-10-22 09:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6132 (online)
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