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Publication Name World Journal of Clinical Oncology
Manuscript ID 127302
Country China
Category Obstetrics & Gynecology
Manuscript Type Retrospective Cohort Study
Article Title Clinical model predicting recurrence after fertility-sparing treatment for endometrial cancer and atypical hyperplasia: Development and external validation
Manuscript Source Unsolicited Manuscript
All Author List Ze-Rui Xiao, Si-Cheng Shen, Lin-Lin Bo, Si-Jia Liu, Yi-Fan Feng, Zhuo-Yu Zhai, Jin Lai, Xiao-Tong Feng, Si-Ru Liu, Xue-Zhen Luo, Jian-Liu Wang, Xing-Chen Li and Yi-Qin Wang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China No. 82501962
Key Project of the National Natural Science Foundation of China No. 82230050
Major Projects of National Science and Technology No. 2025ZD0545900
Research and Development Fund of Peking University People’s Hospital No. RDEB2024-10
Major Projects of National Science and Technology No. 2025ZD0545902
Corresponding Author Yi-Qin Wang, Department of Obstetrics and Gynecology, Peking University People’s Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing 100044, China. emily_wang92@163.com
Key Words Endometrial cancer; Atypical endometrial hyperplasia; Fertility-sparing treatment; Recurrence prediction; Risk score
Core Tip This study developed and externally validated a five-factor model for recurrence-risk stratification after complete remission following fertility-sparing treatment in patients with stage IA endometrial cancer or atypical endometrial hyperplasia. The model demonstrated moderate discriminatory ability in the development and external validation cohorts. It may assist recurrence-risk stratification and individualized follow-up, although further prospective multicenter validation and calibration are warranted before clinical implementation.
Citation Xiao ZR, Shen SC, Bo LL, Liu SJ, Feng YF, Zhai ZY, Lai J, Feng XT, Liu SR, Luo XZ, Wang JL, Li XC, Wang YQ. Clinical model predicting recurrence after fertility-sparing treatment for endometrial cancer and atypical hyperplasia: Development and external validation. World J Clin Oncol 2026; In press
Received
2026-08-27 07:49
Peer-Review Started
2026-08-27 07:49
First Decision by Editorial Office Director
Return for Revision
2026-09-04 02:06
Revised
2026-09-27 12:39
Publication Fee Transferred
Second Decision by Editor
2026-11-10 03:02
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-11-10 10:31
Articles in Press
2026-11-10 10:31
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2218-4333 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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