Publication Name	World Journal of Gastroenterology
Manuscript ID	127326
DOI	10.3748/wjg.127326
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Artificial intelligence-assisted upper gastrointestinal endoscopy for neoplasm detection: Systematic review and meta-analysis of randomized controlled trials
Manuscript Source	Unsolicited Manuscript
All Author List	Sang-ji Choi and Gibong Chae
Funding Agency and Grant Number
Corresponding Author	Sang-ji Choi, MD, PhD, Department of Surgery, Kangwon National University Hospital, 156, Baengnyeong-ro, Chuncheon-si 24289, Kangwon-do, South Korea. goodpaper@kangwon.ac.kr
Key Words	Artificial intelligence; Computer-aided detection; Esophagogastroduodenoscopy; Esophageal neoplasms; Stomach neoplasms; Early detection of cancer; Randomized controlled trials; Systematic review; Meta-analysis
Core Tip	Whether real-time artificial intelligence (AI) improves neoplasm detection during upper gastrointestinal endoscopy remains debated following a large, centrally adjudicated gastric trial that found no significant difference. This systematic review and meta-analysis of 14 randomized trials (90828 participants) found that AI increased per-patient neoplasm detection, with similar estimates for the esophagus and stomach, and no evidence that effects varied by system functionality. The esophageal evidence was homogeneous and of moderate certainty, whereas the gastric evidence remained heterogeneous and of low certainty. AI is a promising adjunct whose clinical benefit requires confirmation.
Citation	Choi SJ, Chae G. Artificial intelligence-assisted upper gastrointestinal endoscopy for neoplasm detection: Systematic review and meta-analysis of randomized controlled trials. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.127326
PDF	127326-in-press.pdf

Received	2026-08-27 03:11
Peer-Review Started	2026-08-27 03:11
First Decision by Editorial Office Director
Return for Revision	2026-09-10 07:40
Revised	2026-09-21 01:37
Publication Fee Transferred	2026-10-10 13:52
Second Decision by Editor	2026-11-02 02:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-04 10:50
Articles in Press	2026-11-04 10:50
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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