Publication Name	World Journal of Diabetes
Manuscript ID	127341
DOI	10.4239/wjd.127341
Country	China

Category	Urology & Nephrology
Manuscript Type	Basic Study
Article Title	Grape seed proanthocyanidin extract attenuates high glucose-induced epithelial-mesenchymal transition of podocytes and alleviates streptozotocin diabetic renal injury
Manuscript Source	Unsolicited Manuscript
All Author List	Zhi-Fang Zheng and Lian Jiang
Funding Agency and Grant Number
Corresponding Author	Lian Jiang, Department of Pediatrics, The Fourth Hospital of Hebei Medical University, No.12 Jiankang Road, Shijiazhuang City, Hebei Province, China, Shijiazhuang 050000, Hebei, China. 46100280@hebmu.edu.cn
Key Words	Diabetic nephropathy; Grape seed proanthocyanidin extract; Podocytes; Epithelial-mesenchymal transition; Oxidative stress; Streptozotocin; Rat model
Core Tip	This study investigated the association between grape seed proanthocyanidin extract (GSPE) and podocyte epithelial-mesenchymal transition (EMT), as well as its potential role in alleviating renal injury in diabetic nephropathy (DN). GSPE attenuated high glucose-induced EMT and abnormal migration in human podocytes, which may be associated with the transforming growth factor-β1/Smad signaling pathway. GSPE alleviated oxidative stress injury and improved hepatic and renal function in diabetic rats, thereby contributing to delaying progression of DN.
Citation	Zheng ZF, Jiang L. Grape seed proanthocyanidin extract attenuates high glucose-induced epithelial-mesenchymal transition of podocytes and alleviates streptozotocin diabetic renal injury. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.127341
PDF	127341-in-press.pdf

Received	2026-08-27 02:56
Peer-Review Started	2026-09-09 09:28
First Decision by Editorial Office Director
Return for Revision	2026-09-20 02:14
Revised	2026-09-29 23:37
Publication Fee Transferred	2026-10-15 07:59
Second Decision by Editor	2026-11-02 03:21
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-09 11:24
Articles in Press	2026-11-09 11:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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