Publication Name	World Journal of Gastroenterology
Manuscript ID	127449
DOI	10.3748/wjg.127449
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Global epidemiology of metabolic dysfunction-associated steatotic liver disease: 2026 update
Manuscript Source	Invited Manuscript
All Author List	Tie Xiao, Nicholas WS Chew, Giovanni Targher, Christopher D Byrne, Gregory YH Lip, Xiao-Dong Zhou and Ming-Hua Zheng
Funding Agency and Grant Number
Corresponding Author	Ming-Hua Zheng, MAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, No. 2 Fuxue Lane, Wenzhou 325000, Zhejiang Province, China. zhengmh@wmu.edu.cn
Key Words	Metabolic dysfunction-associated steatotic liver disease; Metabolic dysfunction-associated steatohepatitis; Epidemiology; Comorbidity; Hepatic and extrahepatic outcomes; Screening; Prevention
Core Tip	The epidemiology of metabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly evolving, driven by a rising global burden and shifting patterns across populations. MASLD is no longer viewed as a simple liver-specific disease but as a condition associated with a broad spectrum of hepatic and extrahepatic complications. Advances in non-invasive diagnostics and new pharmacotherapies are reshaping approaches to disease detection and management. This narrative review summarizes recent updates on MASLD epidemiology and discusses their implications for clinical practice.
Citation	Xiao T, Chew NWS, Targher G, Byrne CD, Lip GYH, Zhou XD, Zheng MH. Global epidemiology of metabolic dysfunction-associated steatotic liver disease: 2026 update. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.127449
PDF	127449-in-press.pdf

Received	2026-09-02 08:35
Peer-Review Started	2026-09-02 08:36
First Decision by Editorial Office Director
Return for Revision	2026-09-28 03:29
Revised	2026-10-05 11:06
Publication Fee Transferred
Second Decision by Editor	2026-10-14 06:11
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-14 08:37
Articles in Press	2026-10-14 08:37
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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