Publication Name	World Journal of Stem Cells
Manuscript ID	127499
DOI	10.4252/wjsc.127499
Country	China

Category	Obstetrics & Gynecology
Manuscript Type	Minireviews
Article Title	Stem cell-based therapy for premature ovarian insufficiency: From mechanisms to clinical translation
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Chun Weng, Shu-Ping Lyu and Hai-Yan Peng
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82301854, 82603233 Youth Clinical Research Program of the Shanghai Municipal Health Commission 20264Y0163 Fundamental Research Funds for the Central Universities YG2026QNA50
Corresponding Author	Shu-Ping Lyu, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China. lv0217shuping@163.com
Key Words	Premature ovarian insufficiency; Stem cell therapy; Mesenchymal stem cells; Ovarian regeneration; Clinical studies
Core Tip	Premature ovarian insufficiency, characterized by ovarian dysfunction before age 40, causes infertility, menopausal symptoms, and long-term health risks, while hormonal therapy does not restore ovarian reserve or fertility. Stem cell-based therapies show regenerative potential, particularly mesenchymal stem/stromal cells and extracellular vesicles, through anti-apoptotic, antioxidant, angiogenic, immunomodulatory, and paracrine effects. Emerging gene-modified cells and cell-free products may enhance therapeutic precision and translational feasibility. However, clinical evidence remains limited and heterogeneous. Future progress requires mechanism-guided optimization, standardized manufacturing and potency assessment, appropriate delivery strategies, and rigorously designed randomized controlled trials to establish long-term safety and efficacy.
Citation	Weng LC, Lyu SP, Peng HY. Stem cell-based therapy for premature ovarian insufficiency: From mechanisms to clinical translation. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.127499
PDF	127499-in-press.pdf

Received	2026-08-31 07:16
Peer-Review Started	2026-08-31 07:16
First Decision by Editorial Office Director
Return for Revision	2026-09-08 03:14
Revised	2026-09-22 08:36
Publication Fee Transferred	2026-10-21 10:54
Second Decision by Editor	2026-10-23 11:31
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-05 09:11
Articles in Press	2026-11-05 09:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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