Publication Name	World Journal of Clinical Cases
Manuscript ID	127546
DOI	10.12998/wjcc.127546
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Esophageal stricture due to amyloidosis in plasma cell dyscrasia: A case report and review of literature
Manuscript Source	Invited Manuscript
All Author List	Sanjeev Sachdeva, Nikhil Sirohi, koushik mandal, Dhruv Bansal, Venkatesh Vaithiyam, Ashok Dalal, Surbhi Goyal and Puja Sakhuja
Funding Agency and Grant Number
Corresponding Author	Venkatesh Vaithiyam, Consultant, DM, MD, Department of Gastroenterology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, 80 Feet Road, Lake View Road, Deputy Collector Colony, New Delhi 110002, Delhi, India. venkateshvaithiyam172@gmail.com
Key Words	Amyloidosis; Dysphagia; Esophageal stricture; Plasma cell dyscrasia; Balloon dilatation; Congo red staining; Case report
Core Tip	Esophageal involvement in systemic amyloidosis is rare and presents in variable ways. We report a 65-year-old woman with progressive dysphagia, weight loss, and an upper esophageal stricture. Biopsy demonstrated Congo red-positive amyloid with lambda light-chain restriction, and bone marrow examination revealed approximately 50% lambda-restricted plasma cells, establishing an underlying plasma-cell dyscrasia. Although fat-pad and rectal biopsies were negative, a direct esophageal biopsy confirmed amyloid deposition at the site of disease. Endoscopic balloon dilation resulted in complete resolution of dysphagia, and daratumumab, bortezomib, cyclophosphamide, and dexamethasone therapy was initiated for disease modification.
Citation	Sachdeva S, Sirohi N, mandal K, Bansal D, Vaithiyam V, Dalal A, Goyal S, Sakhuja P. Esophageal stricture due to amyloidosis in plasma cell dyscrasia: A case report and review of literature. World J Clin Cases 2026; In press DOI: https://doi.org/10.12998/wjcc.127546
PDF	127546-in-press.pdf

Received	2026-09-01 03:41
Peer-Review Started	2026-09-01 03:42
First Decision by Editorial Office Director
Return for Revision	2026-09-23 07:21
Revised	2026-10-04 05:38
Publication Fee Transferred
Second Decision by Editor	2026-10-20 07:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-20 09:37
Articles in Press	2026-10-20 09:37
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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