Publication Name	World Journal of Nephrology
Manuscript ID	127590
DOI	10.5527/wjn.127590
Country	Türkiye

Category	Urology & Nephrology
Manuscript Type	Observational Study
Article Title	Serum complement 5a and complement 5a receptor-1 levels in children with chronic kidney disease
Manuscript Source	Invited Manuscript
All Author List	Kaan Savas Gulleroglu, Ayşegül Atak Yücel, Esra Sidika Baskin, Feride İffet Sahin, Melek Yaman and Selin Akad Dinçer
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research Projects (BAP) Unit of Gazi University TDK-2022-7599
Corresponding Author	Kaan Savas Gulleroglu, MD, PhD, Professor, Department of Immunology, Gazi University, Graduate School of Health Science,, Department of Immunology, Graduate School of Health Science, Gazi University, Ankara, Turkey, Ankara 06410, Türkiye. kaangulleroglu@yahoo.com
Key Words	Chronic kidney disease; Pediatrics; Complement 5a; Complement 5a receptor-1; Renal fibrosis; Inflammation
Core Tip	Animal models and in vitro studies show that inflammatory stimulation upregulates complement 3a, 5a, and their receptors in the renal cortex, thereby promoting renal fibrosis. However, the exact association of these complement components with pediatric chronic kidney disease (CKD) remains poorly understood. Our findings indicate a trending, approximately two-fold increase in serum C5a levels among patients with stage 5 CKD compared with earlier stages, although this did not reach statistical significance. Conversely, serum C3 values were significantly decreased, suggesting that these specific complement alterations might be closely linked to chronic systemic inflammation in these patients.
Citation	Gulleroglu KS, Yücel AA, Baskin ES, Sahin Fİ, Yaman M, Selin Akad Dinçer. Serum complement 5a and complement 5a receptor-1 levels in children with chronic kidney disease. World J Nephrol 2026; In press DOI: https://doi.org/10.5527/wjn.127590
PDF	127590-in-press.pdf

Received	2026-09-02 08:35
Peer-Review Started	2026-09-02 08:36
First Decision by Editorial Office Director
Return for Revision	2026-09-16 07:45
Revised	2026-10-19 11:09
Publication Fee Transferred
Second Decision by Editor	2026-11-09 06:13
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-09 11:29
Articles in Press	2026-11-09 11:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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