Publication Name	World Journal of Psychiatry
Manuscript ID	127787
Country	China

Category	Psychiatry
Manuscript Type	Retrospective Cohort Study
Article Title	Associations of ferroptosis-related biomarkers with psychiatric symptoms after sepsis with reduced left ventricular ejection fraction
Manuscript Source	Unsolicited Manuscript
All Author List	Zong-Jiang Bai, Xiao-Tian Han, Yan Shao and Ya-Zhou Li
Funding Agency and Grant Number	Funding Agency Grant Number Medical Science Research Project of Hebei Provincial Health Commission 20250699
Corresponding Author	Ya-Zhou Li, MD, Department of Emergency, The Fourth Hospital of Hebei Medical University, No. 12 Health Road, Chang’an District, Shijiazhuang 050011, Hebei Province, China. 18533167609@163.com
Key Words	Sepsis; Reduced left ventricular ejection fraction; Ferroptosis; Glutathione peroxidase 4; Acyl-CoA synthetase long-chain family member 4; Post-intensive care syndrome; Depression; Anxiety; Post-traumatic stress symptoms
Core Tip	Among 200 sepsis survivors with reduced left ventricular ejection fraction, 44.0% met a depression, anxiety, or post-traumatic stress screening threshold approximately three months after discharge. After adjustment for prespecified clinical covariates, lower glutathione peroxidase 4 and higher acyl-CoA synthetase long-chain family member 4 were associated with the composite symptom outcome. Measurement-availability analyses showed similar baseline profiles and outcome prevalence in the four-biomarker complete group and the group with at least one unavailable assay. The findings are association-focused and do not establish causality, brain-tissue ferroptosis, or validated prognostic performance.
Citation	Bai ZJ, Han XT, Shao Y, Li YZ. Associations of ferroptosis-related biomarkers with psychiatric symptoms after sepsis with reduced left ventricular ejection fraction. World J Psychiatry 2026; In press

Received	2026-09-29 10:28
Peer-Review Started	2026-09-29 10:29
First Decision by Editorial Office Director
Return for Revision	2026-10-15 03:31
Revised	2026-10-22 10:11
Publication Fee Transferred
Second Decision by Editor	2026-11-10 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-10 10:32
Articles in Press	2026-11-10 10:32
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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