Publication Name	World Journal of Orthopedics
Manuscript ID	127949
DOI	10.5312/wjo.127949
Country	China

Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Natural bioactive compounds in estrogen deficiency-induced osteoporosis: Classification and an integrated gut microbiota-metabolite-immune-bone framework
Manuscript Source	Invited Manuscript
All Author List	Long Luo, Tao Zhang and Wen-Sheng Xu
Funding Agency and Grant Number	Funding Agency Grant Number Graduate Research and Innovation Project of Baotou Medical College BYKYCX202606 Natural Science Foundation of Inner Mongolia 2022MS08039
Corresponding Author	Wen-Sheng Xu, PhD, Department of Joint Surgery, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, No. 41 Linyin Road, Kundulun District, Baotou 014000, Inner Mongolia Autonomous Region, China. xwsoye@126.com
Key Words	Natural bioactive compounds; Postmenopausal osteoporosis; Gut microbiota; Phytoestrogens; Short-chain fatty acids; Th17/Treg; Microrna; Extracellular vesicles; Gut-bone axis
Core Tip	This minireview introduces a microbiota-dependent classification of natural bioactive compounds for estrogen deficiency-induced osteoporosis and proposes an integrated gut-metabolite-immune-bone framework. Rather than acting solely on bone cells, these interventions may reshape microbial metabolites, intestinal barrier function, estrogen availability, immune balance, and post-transcriptional regulation. This framework highlights priorities for causal multi-omics studies, microbiota-stratified trials, and the clinical evaluation of individualized nutrition-based interventions as potential adjunctive strategies.
Citation	Luo L, Zhang T, Xu WS. Natural bioactive compounds in estrogen deficiency-induced osteoporosis: Classification and an integrated gut microbiota-metabolite-immune-bone framework. World J Orthop 2026; In press DOI: https://doi.org/10.5312/wjo.127949
PDF	127949-in-press.pdf

Received	2026-09-11 06:51
Peer-Review Started	2026-09-21 08:11
First Decision by Editorial Office Director
Return for Revision	2026-10-08 05:53
Revised	2026-10-16 13:16
Publication Fee Transferred
Second Decision by Editor	2026-11-02 02:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-02 02:56
Articles in Press	2026-11-02 02:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
Open Access	Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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