Publication Name	World Journal of Experimental Medicine
Manuscript ID	128106
DOI	10.5493/wjem.128106
Country	Italy

Category	Ophthalmology
Manuscript Type	Minireviews
Article Title	Neutrophil extracellular traps and immunothrombosis in ocular diseases: Emerging mechanisms, fluid biomarkers, and therapeutic targets
Manuscript Source	Invited Manuscript
All Author List	Matteo Capobianco, Francesco Cappellani, Ehimare Enaholo, Caterina Gagliano and Marco Zeppieri
Funding Agency and Grant Number
Corresponding Author	Marco Zeppieri, Consultant, MD, PhD, Postdoc, Department of Ophthalmology, University Hospital of Udine, p. le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it
Key Words	Neutrophil extracellular traps; Immunothrombosis; Ocular inflammation; Dry eye disease; Diabetic retinopathy; Retinal vein occlusion; Biomarkers
Core Tip	Neutrophil extracellular traps (NETs) are increasingly recognized as mediators at the interface between innate immunity, inflammation, endothelial injury, and thrombosis. In the eye, NET-associated pathways have been implicated most consistently in dry eye disease, ocular graft-vs-host disease, infectious keratitis, diabetic retinopathy, and retinal vascular disease, while emerging evidence extends to uveitis, age-related macular degeneration, and glaucoma. However, NETs are not uniformly pathogenic: Their antimicrobial activity and their ability to participate in vascular remodeling indicate important context-dependent protective functions. Molecular mechanisms of NET formation and clearance are important in understanding the importance of NETs.
Citation	Capobianco M, Cappellani F, Enaholo E, Gagliano C, Zeppieri M. Neutrophil extracellular traps and immunothrombosis in ocular diseases: Emerging mechanisms, fluid biomarkers, and therapeutic targets. World J Exp Med 2026; In press DOI: https://doi.org/10.5493/wjem.128106
PDF	128106-in-press.pdf

Received	2026-09-15 02:44
Peer-Review Started	2026-09-15 02:44
First Decision by Editorial Office Director
Return for Revision	2026-10-27 06:06
Revised	2026-11-02 10:49
Publication Fee Transferred
Second Decision by Editor	2026-11-12 05:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-12 10:07
Articles in Press	2026-11-12 10:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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