Publication Name	World Journal of Clinical Cases
Manuscript ID	128223
Country	Japan

Category	Psychiatry
Manuscript Type	Case Report
Article Title	Suspected donepezil withdrawal syndrome in an older woman with Alzheimer disease of abrupt cessation: A case report
Manuscript Source	Invited Manuscript
All Author List	Takahiko Nagamine
Funding Agency and Grant Number
Corresponding Author	Takahiko Nagamine, Department of Psychiatric Internal Medicine, Sunlight Brain Research Center, 4-13-18 Jiyugaoka, Hofu 7470066, Yamaguchi, Japan. anagamine@yahoo.co.jp
Key Words	Donepezil; Withdrawal syndrome; Delirium; Behavioral and psychological symptoms of dementia; Nursing-home admission; Older adults; Case report
Core Tip	Abrupt discontinuation of long-term donepezil was followed 48 hours later by agitation, insomnia and gait instability in an 89-year-old woman who had taken 10 mg/day for more than five years. Symptoms improved after rechallenge with 5 mg/day, but interpretation is limited by pre-existing cognitive decline, nursing-home relocation, concomitant quetiapine and other unmeasured factors. The case illustrates why suspected withdrawal may be considered in the differential diagnosis without assuming that all post-discontinuation deterioration is drug-related.
Citation	Nagamine T. Suspected donepezil withdrawal syndrome in an older woman with Alzheimer disease of abrupt cessation: A case report. World J Clin Cases 2026; In press

Received	2026-09-17 03:39
Peer-Review Started	2026-09-17 03:40
First Decision by Editorial Office Director
Return for Revision	2026-09-29 06:32
Revised	2026-09-30 00:20
Publication Fee Transferred
Second Decision by Editor	2026-10-10 08:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-10 09:01
Articles in Press	2026-10-10 09:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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