Publication Name	World Journal of Clinical Cases
Manuscript ID	128280
Country	United States

Category	Hematology
Manuscript Type	Case Report
Article Title	Severe Hageman factor (factor XII) deficiency discovered during evaluation of palpitations and chest pain: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Zakaria M Ahmed and Ilyas M Ahmed
Funding Agency and Grant Number
Corresponding Author	Zakaria M Ahmed, Department of Internal Medicine, University at Buffalo Catholic Health System, 565 Abbott Road, Buffalo, NY 14220, United States. zakariamahmed2001@gmail.com
Key Words	Hageman factor; Factor XII deficiency; Activated partial thromboplastin time; Incidental finding; Thromboembolism; Case report
Core Tip	Severe factor XII (FXII) deficiency causes a markedly prolonged activated partial thromboplastin time (APTT) without bleeding and is usually found incidentally. We report a 36-year-old man in whom FXII activity of < 1% was discovered during evaluation for transient palpitations, chest pain and dyspnea. Extensive evaluation found no thrombotic, ischemic or bleeding cause, and the deficiency is not considered the cause of his symptoms. An isolated, markedly prolonged APTT warrants systematic work-up, but symptoms should be assessed on their own merits.
Citation	Ahmed ZM, Ahmed IM. Severe Hageman factor (factor XII) deficiency discovered during evaluation of palpitations and chest pain: A case report. World J Clin Cases 2026; In press

Received	2026-09-20 07:45
Peer-Review Started	2026-09-20 07:45
First Decision by Editorial Office Director
Return for Revision	2026-09-28 22:43
Revised	2026-10-06 02:46
Publication Fee Transferred	2026-10-29 01:19
Second Decision by Editor	2026-11-10 03:00
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-10 10:32
Articles in Press	2026-11-10 10:32
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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