Publication Name	World Journal of Hepatology
Manuscript ID	32372
Country	Argentina

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients
Manuscript Source	Invited Manuscript
All Author List	Natalia Laufer, Diego Ojeda, María Laura Polo, Ana Martinez, Héctor Pérez, Gabriela Turk, Pedro Cahn, Norberto Walter Zwirner and Jorge Quarleri
Funding Agency and Grant Number
Corresponding Author	Natalia Laufer, MD, PhD, Investigador Asistente – CONICET, Instituto Investigaciones Biomédicas en Retrovirus y SIDA INBIRS, Universidad de Buenos Aires. Paraguay 2155 Piso 11, Buenos Aires C1121ABG, Argentina. nlaufer@fmed.uba.ar
Key Words	CD4+ T cell; Human immunodeficiency virus/hepatitis C virus-coinfection; Fibrosis; Biomarker; Natural killer cells
Core Tip	Approximately 2.3 million individuals with human immunodeficiency virus are coinfected with hepatitis C virus (HCV). The high cost of HCV treatment restricts its use. It is crucial to identify patients with advanced liver fibrosis with an urgent need of treatment. The aim of this study was to identify natural killer (NK) phenotypes as a biomarker for liver fibrosis. We observed that those subjects with higher fibrosis are those with lower percentage of NK cells and also with lower LTCD4+ count. These constitute two simple parameters that might be performed in a routine laboratory test and used in clinical practice as biomarkers for liver fibrosis.
Citation	Laufer N, Ojeda D, Polo ML, Martinez A, Pérez H, Turk G, Cahn P, Zwirner NW, Quarleri J. CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients. World J Hepatol 2017; 9(25): 1073-1080

Received	2017-01-05 09:56
Peer-Review Started	2017-01-07 08:41
To Make the First Decision	2017-04-17 15:53
Return for Revision	2017-04-20 15:28
Revised	2017-04-29 00:45
Second Decision	2017-05-17 09:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-05-24 01:03
Articles in Press	2017-05-24 01:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-08-25 08:04

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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