Publication Name	World Journal of Clinical Oncology
Manuscript ID	32579
Country	Peru

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Metronomic chemotherapy for non-metastatic triple negative breast cancer: Selection is the key
Manuscript Source	Invited Manuscript
All Author List	Connie Rabanal, Rossana Ruiz, Silvia Neciosup and Henry Gomez
Funding Agency and Grant Number
Corresponding Author	Connie Rabanal, MD, Department of Medical Oncology, Instituto Nacional de Enfermedades Neoplasicas, Av. Angamos Este 2520, Lima 15038, Peru. connie.rabanal@hotmail.com
Key Words	Metronomic chemotherapy; Triple negative breast cancer; Neoadjuvant; Adjuvant; Maintenance
Core Tip	Triple negative breast cancer (TNBC) is the only type of breast cancer for which there are no approved targeted therapies. Metronomic chemotherapy (MC) is being explored as an alternative to improve outcomes in TNBC. In neoadjuvant setting, purely metronomic and hybrid approaches achieve complete pathologic response (pCR) rates between 47%-60%, but at the cost of great toxicity. In the adjuvant setting, MC is used to intensify adjuvant chemotherapy and, promisingly, as maintenance therapy for high-risk patients, especially those with no pCR. Considering the dismal prognosis of TNBC, any strategy that improves outcomes, specially being broadly available and inexpensive, should be considered.
Citation	Rabanal C, Ruiz R, Neciosup S, Gomez H. Metronomic chemotherapy for non-metastatic triple negative breast cancer: Selection is the key. World J Clin Oncol 2017; 8(6): 437-446

Received	2017-01-16 08:46
Peer-Review Started	2017-01-16 16:39
To Make the First Decision	2017-04-17 09:24
Return for Revision	2017-05-02 19:38
Revised	2017-08-11 23:59
Second Decision	2017-08-25 07:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-09-16 19:18
Articles in Press	2017-09-16 19:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-11-28 04:06

ISSN	2218-4333 (online)
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