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Publication Name World Journal of Gastroenterology
Manuscript ID 32700
Country/Territory Germany
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Helicobacter pylori vacA genotype is a predominant determinant of immune response to Helicobacter pylori CagA
Manuscript Source Invited Manuscript
All Author List Alexander Link, Cosima Langner, Wiebke Schirrmeister, Wiebke Habendorf, Jochen Weigt, Marino Venerito, Ina Tammer, Dirk Schlüter, Philipp Schlaermann, Thomas F Meyer, Thomas Wex and Peter Malfertheiner
Funding Agency and Grant Number
Funding Agency Grant Number
the frame of ERA-NET PathoGenoMics BMBF-0315905D
Corresponding Author Alexander Link, MD, PhD, Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany. alexander.link@med.ovgu.de
Key Words Helicobacter pylori; Seropositivity; Virulence factors; CagA; VacA; Immune response
Core Tip Helicobacter pylori (H. pylori) related diseases are commonly associated with cagA+ strains, although seropositivity against CagA varies among different studies. In this prospective study, we evaluated potential factors related to the H. pylori CagA-immune response. We show that anti-CagA-IgG seropositivity was strongly associated with histopathological and inflammatory factors. Most importantly, we identified H. pylori vacA polymorphism as one of the main determinants of immune response to CagA and inflam­matory potential of H. pylori strains ex vivo and in vitro. Our data support the crucial role of bacterial factors that co-determine the complex interaction with H. pylori and define the immune and clinical phenotypes of the infection.
Citation Link A, Langner C, Schirrmeister W, Habendorf W, Weigt J, Venerito M, Tammer I, Schlüter D, Schlaermann P, Meyer TF, Wex T, Malfertheiner P. Helicobacter pylori vacA genotype is a predominant determinant of immune response to Helicobacter pylori CagA. World J Gastroenterol 2017; 23(26): 4712-4723
Received
2017-01-20 10:09
Peer-Review Started
2017-01-22 13:09
To Make the First Decision
2017-03-16 13:20
Return for Revision
2017-03-20 16:45
Revised
2017-04-05 05:42
Second Decision
2017-05-18 03:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-05-19 07:56
Articles in Press
2017-05-19 07:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-07-01 03:12
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work noncommercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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