Publication Name	World Journal of Gastroenterology
Manuscript ID	32967
Country	Slovakia

Category	Pharmacology & Pharmacy
Manuscript Type	Basic Study
Article Title	Indole phytoalexin derivatives induce mitochondrial-mediated apoptosis in human colorectal carcinoma cells
Manuscript Source	Invited Manuscript
All Author List	Viera Tischlerova, Martin Kello, Mariana Budovska and Jan Mojzis
Funding Agency and Grant Number	Funding Agency Grant Number Grants of the Slovak Grant Agency for Science VEGA 1/0322/14 Grants of the Slovak Grant Agency for Science VEGA 1/0753/17
Corresponding Author	Jan Mojzis, Professor, DVM, DSc, Department of Pharmacology, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovak Republic. jan.mojzis@upjs.sk
Key Words	Colorectal carcinoma; Indole phytoalexins; Antiproliferative; Apoptosis; Intrinsic pathway
Core Tip	In this study we inform about our first results obtained from cell proliferation assays, flow cytometry analysis and Western blot analysis of HCT116 cells after treatment with compound K-453, which belongs to a group of synthetic derivatives of indole phytoalexins originally isolated from cruciferous vegetables. This study demonstrates that our compound induces the mitochondrial pathway of apoptosis and that the antiproliferative effect of our substance may be linked to inhibition of several signaling pathways. Our results provide a rationale for further in vivo anticancer efficacy studies.
Citation	Tischlerova V, Kello M, Budovska M, Mojzis J. Indole phytoalexin derivatives induce mitochondrial-mediated apoptosis in human colorectal carcinoma cells. World J Gastroenterol 2017; 23(24): 4341-4353

Received	2017-02-01 12:45
Peer-Review Started	2017-02-02 13:45
To Make the First Decision	2017-03-16 13:18
Return for Revision	2017-03-20 16:51
Revised	2017-03-27 20:53
Second Decision	2017-05-18 03:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-05-19 07:59
Articles in Press	2017-05-19 07:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-21 02:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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