Publication Name	World Journal of Gastroenterology
Manuscript ID	33189
Country	Poland

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Levels and activities of von Willebrand factor and metalloproteinase with thrombospondin type-1 motif, number 13 in inflammatory bowel diseases
Manuscript Source	Invited Manuscript
All Author List	Dorota Cibor, Danuta Owczarek, Saulius Butenas, Kinga Salapa, Tomasz Mach and Anetta Undas
Funding Agency and Grant Number
Corresponding Author	Danuta Owczarek, MD, PhD, Department of Gastroenterology, Hepatology and Infectious Diseases, Jagiellonian University Medical College, ul. Sniadeckich 5, 31-531 Krakow, Poland. owczarek@su.krakow.pl
Key Words	ADAMTS13; Inflammatory bowel disease; Thrombosis; Acquired von Willebrand syndrome; von Willebrand factor
Core Tip	A tightly regulated balance between von Willebrand factor and metalloproteinase with throm­bospondin type-1 motif, number 13 (ADAMTS13) is important for haemostasis, and its dysregulation might predispose one to either thrombotic events or bleeding. We demonstrated a decrease in ADAMTS13act levels in Crohn’s disease (CD) patients, and in ADAMTS13:Ag and ADAMTS13act in ulcerative colitis (UC) patients, in whom these parameters were negatively correlated with disease activity and inflammatory markers. We report for the first time the presence of abnormalities typical of type A2 acquired von Willebrand syndrome in inflammatory bowel disease patients. These findings provide insight into the elevated risk for thromboembolic events and bleeding observed in UC and less frequently in CD.
Citation	Cibor D, Owczarek D, Butenas S, Salapa K, Mach T, Undas A. Levels and activities of von Willebrand factor and metallo­proteinase with thrombospondin type-1 motif, number 13 in inflammatory bowel diseases. World J Gastroenterol 2017; 23(26): 4796-4805

Received	2017-02-08 16:05
Peer-Review Started	2017-02-10 10:53
To Make the First Decision	2017-03-03 10:05
Return for Revision	2017-03-07 10:40
Revised	2017-04-07 07:07
Second Decision	2017-05-18 03:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-05-19 07:59
Articles in Press	2017-05-19 07:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-07-01 06:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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