Publication Name	World Journal of Gastroenterology
Manuscript ID	33214
Country	Italy

Category	Oncology
Manuscript Type	Review
Article Title	Implication of the Hedgehog pathway in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Carminia Maria Della Corte, Giuseppe Viscardi, Federica Papaccio, Giovanna Esposito, Giulia Martini, Davide Ciardiello, Erika Martinelli, Fortunato Ciardiello and Floriana Morgillo
Funding Agency and Grant Number
Corresponding Author	Floriana Morgillo, MD, PhD, Assistant Professor, Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale “F. Magrassi e A. Lanzara”, Università degli studi della Campania “Luigi Vanvitelli”, Via S. Pansini 5, 80131 Naples, Italy. florianamorgillo@yahoo.com
Key Words	Hedgehog; epithelial-mesenchymal transition; hepatocellular carcinoma; hepatocarcinogenesis; prognosis
Core Tip	The hedgehog (HH) pathway is involved in the embryonic development of liver, and its reactivation plays a substantial role in sustaining cancer cell growth and progression in hepatocellular carcinoma (HCC). In hepatocarcinogenesis, HH signalling is required for differentiation, proliferation and polarity of liver embryonic cells. High levels of expression of HH com­ponents in HCC tissues correlate with mesenchymal properties and maintain the proliferation of cancer stem cells, which is a dynamic source of malignant cells in HCC progression. Current data on HH inhibition in preclinical models further confirm the role of HH and deserve future investigations in a clinical setting.
Citation	Della Corte cm, Viscardi G, Papaccio F, Esposito G, Martini G, Ciardiello D, Martinelli E, Ciardiello F, Morgillo F. Implication of the Hedgehog pathway in hepatocellular carcinoma. World J Gastroenterol 2017; 23(24): 4330-4340

Received	2017-02-07 18:53
Peer-Review Started	2017-02-10 09:03
To Make the First Decision	2017-03-16 11:51
Return for Revision	2017-03-21 11:37
Revised	2017-04-13 23:50
Second Decision	2017-05-15 08:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-05-19 08:19
Articles in Press	2017-05-19 08:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-16 01:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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