Publication Name	World Journal of Gastroenterology
Manuscript ID	33433
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Effect of EPEC endotoxin and bifidobacteria on intestinal barrier function through modulation of toll-like receptor 2 and toll-like receptor 4 expression in intestinal epithelial cell-18
Manuscript Source	Unsolicited Manuscript
All Author List	Xia Yang, Xian-Chun Gao, Jun Liu and Hong-Yu Ren
Funding Agency and Grant Number	Funding Agency Grant Number Medjaden Academy & Research Foundation for Young Scientists MJA20170410
Corresponding Author	Hong-Yu Ren, MD, PhD, Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan 430022, Hubei Province, China. hongyur@hotmail.com
Key Words	Bifidobacteria; Intestinal barrier function; Intestinal epithelial cells
Core Tip	toll-like receptors (TLRs) are key components of the innate immune system that trigger antimicrobial host defense responses. EPEC promoted the expression of toll-like receptors 2 (TLR2) and TLR4 and increased cell membrane perme­ability, where as bifidobacteria inhibited the expression of TLR2 and TLR4 and prevented TLR-mediated inflammation. Therefore, bifidobacteria can potentially play a protective role by inhibiting inflammation and preventing penetration of pathogenic bacteria in patients with inflammatory bowel disease.
Citation	Yang X, Gao XC, Liu J, Ren HY. Effect of EPEC endotoxin and bifidobacteria on intestinal barrier function through modulation of toll-like receptor 2 and toll-like receptor 4 expression in intestinal epithelial cell-18. World J Gastroenterol 2017; 23(26): 4744-4751

Received	2017-02-10 09:48
Peer-Review Started	2017-02-11 21:40
To Make the First Decision	2017-03-16 11:51
Return for Revision	2017-03-21 11:32
Revised	2017-04-23 23:20
Second Decision	2017-05-15 08:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-05-19 08:25
Articles in Press	2017-05-19 08:25
Publication Fee Transferred	2017-05-23 13:25
Edit the Manuscript by Language Editor	2017-06-17 01:32
Typeset the Manuscript	2017-06-28 10:02

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com