Publication Name	World Journal of Gastroenterology
Manuscript ID	33550
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Partners of patients with ulcerative colitis exhibit a biologically relevant dysbiosis in fecal microbial metacommunities
Manuscript Source	Unsolicited Manuscript
All Author List	Guang-Lan Chen, Ye Zhang, Wang-Yue Wang, Xue-Liang Ji, Fei Meng, Pei-Song Xu, Ning-Min Yang, Fu-Qiang Ye and Xiao-Chen Bo
Funding Agency and Grant Number	Funding Agency Grant Number Lishui Science and Technology Bureau Research Fund 2013JYZB43 Medical and Health Science and Technology Plan Project of Zhejiang Province 2015KYB371
Corresponding Author	Dr. Xiao-Chen Bo, Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, People’s Republic of China, Beijing 100089, China. boxc@bmi.ac.cn
Key Words	Ulcerative colitis; Patients; Healthy partner; Fecal microbial communities; Microbiota dysbiosis
Core Tip	To identify the influence on the gut microbial community between ulcerative colitis (UC) patients and their healthy partners, we investigated the gut bacterial community using 16S rRNA amplicon sequencing. The results showed that fecal microbial communities were more similar in UC patients, which had a lower relative abundance of Firmicutes bacteria. Microbiota dysbiosis was also founded in healthy partners. The pathways involved in lipid and nucleotide metabolism were more abundant in the UC patients. The membrane transport and metabolism of cofactors and vitamins pathways were significantly enriched in the healthy partners. Microbial composition might be affected in healthy partners cohabiting with UC patients.
Citation	Chen GL, Zhang Y, Wang WY, Ji XL, Meng F, Xu PS, Yang NM, Bo XC. Partners of patients with ulcerative colitis exhibit a biologically relevant dysbiosis in fecal microbial metacommunities. World J Gastroenterol 2017; 23(25): 4624-4631

Received	2017-02-16 09:14
Peer-Review Started	2017-02-16 21:44
To Make the First Decision	2017-04-07 17:20
Return for Revision	2017-04-07 17:25
Revised	2017-04-10 17:01
Second Decision	2017-05-18 03:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-05-19 08:00
Articles in Press	2017-05-19 08:00
Publication Fee Transferred	2017-05-27 07:33
Edit the Manuscript by Language Editor	2017-06-01 10:39
Typeset the Manuscript	2017-06-24 09:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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