Publication Name	World Journal of Hepatology
Manuscript ID	33640
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Value of quality of life analysis in liver cancer: A clinician’s perspective
Manuscript Source	Invited Manuscript
All Author List	Leung Li and Winnie Yeo
Funding Agency and Grant Number
Corresponding Author	Winnie Yeo, MBBS (Lond), AKC (Lond), FHKCP(HK), FHKAM(HK), FRCP (Lond), FRCP (Edin), Professor, Department of Clinical Oncology, Prince of Wales Hospital, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, NT, Hong Kong, China. winnieyeo@cuhk.edu.hk
Key Words	Hepatocellular carcinoma; Health related quality of life; Palliative care; Prognosis; Survival; The European Organisation for Research and Treatment of Cancer QLQ-C30; QLQ-HCC18; Index score; Functional Assessment of Cancer Therapy; EQ-5D; Spitzer; Short form 36; FHSI-8; World Health Organization Quality of Life Assessment
Core Tip	Health related quality of life (HRQOL) is an important clinical parameter and research endpoint in hepatocellular carcinoma (HCC) patients. Instruments discussed are short form (SF)-36, SF-12, EQ-5D, World Health Organization Quality of Life Assessment (WHOQOL) 100, WHOQOL-BREF, the European Organi­sa­tion for Research and Treatment of Cancer (EORTC) QLQ-C30, Functional Assessment of Cancer Therapy (FACT)-G, Spitzer QoL index, EORTC QLQ-HCC18, FACT-Hep, FHSI-8, TOI. Important utilization of HRQOL included measure­ment and monitoring of HRQOL, treatment endpoint in clinical trial, prognostication of survival, benchmarking of palliative care service and health care valuation. Various difficulties in using HRQOL data in research and clinical practice, including choosing a suitable instrument, missing data, data interpretation, analysis and presentation are explained. Potential solutions are also discussed.
Citation	Li L, Yeo W. Value of quality of life analysis in liver cancer: A clinician’s perspective. World J Hepatol 2017; 9(20): 867-883

Received	2017-02-22 08:32
Peer-Review Started	2017-02-26 23:58
To Make the First Decision	2017-03-27 12:15
Return for Revision	2017-03-29 15:02
Revised	2017-04-10 21:16
Second Decision	2017-05-16 04:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-05-24 00:54
Articles in Press	2017-05-24 00:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-07-08 05:44

ISSN	1948-5182 (online)
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