Publication Name	World Journal of Gastroenterology
Manuscript ID	33696
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Eubiotic properties of rifaximin: Disruption of the traditional concepts in gut microbiota modulation
Manuscript Source	Invited Manuscript
All Author List	Francesca Romana Ponziani, Maria Assunta Zocco, Francesca D'Aversa, Maurizio Pompili and Antonio Gasbarrini
Funding Agency and Grant Number
Corresponding Author	Dr. Francesca R Ponziani MD, Division of Internal Medicine and Gastroenterology, Agostino Gemelli Hospital, largo Agostino Gemelli 8, 00168 Rome, Italy. francesca.ponziani@yahoo.it
Key Words	Intestinal bacteria; Antibiotic; Rifaximin; Gut microbiota; Eubiosis; Dysbiosis; Gut microbiota modulation
Core Tip	The traditional use of antibiotics in the clinical practice is to antagonize local or systemic infections. However, antibiotics induce several alterations of the gut microbiota, including the reduction of beneficial bacteria as well as of microbial diversity. Rifaximin is a non-absorbable antibiotic with broad-spectrum activity and non-traditional antimicrobial effects. Rifaximin has the potential to induce a positive modulation of the gut microbiota, favoring the growth of bacteria beneficial to the host without altering its overall composition. Therefore, rifaximin can be defined not only as an antibiotic but also as an “eubiotic”, namely a positive modulator of the gut ecosystem.
Citation	Ponziani FR, Zocco MA, D’Aversa F, Pompili M, Gasbarrini A. Eubiotic properties of rifaximin: Disruption of the traditional concepts in gut microbiota modulation. World J Gastroenterol 2017; 23(25): 4491-4499

Received	2017-02-27 10:30
Peer-Review Started	2017-02-27 21:54
To Make the First Decision	2017-04-07 17:19
Return for Revision	2017-04-07 17:27
Revised	2017-04-14 19:03
Second Decision	2017-05-18 03:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-05-19 08:00
Articles in Press	2017-05-19 08:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-22 03:59

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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