Publication Name	World Journal of Gastroenterology
Manuscript ID	33711
Country	China

Category	Oncology
Manuscript Type	Case Report
Article Title	Benefit of everolimus in treatment of an intrahepatic cholangiocarcinoma patient with a PIK3CA mutation
Manuscript Source	Unsolicited Manuscript
All Author List	Ji-Lai Bian, Mei-Mei Wang, En-Juan Tong, Jing Sun, Ming Li, Zhi-Bo Miao, Yan-Lin Li, Bai-Hong Zhu and Jia-Jia Xu
Funding Agency and Grant Number
Corresponding Author	Dr. Ji-lai Bian, Department of Medical Oncology, The Fifth People's Hospital of Dalian, Dalian 116021, Liaoning Province, China. bianjilai123@126.com
Key Words	Everolimus; Next generation sequencing; PIK3CA; Intrahepatic cholangiocarcinoma
Core Tip	We report a stage IV intrahepatic cholan¬giocarcinoma (ICC) patient harboring a PIK3CA mutation who responded well to the mTOR inhibitor everolimus. Computed tomography and magnetic resonance imaging demonstrated shrinkage of the tumor and the maintenance of partial response for 6.5 mo after everolimus treatment as the best response. To the best of our knowledge, this is the first clinical case report in the literature of an ICC patient with PIK3CA mutation deriving benefit from everolimus treatment.
Citation	Bian JL, Wang MM, Tong EJ, Sun J, Li M, Miao ZB, Li YL, Zhu BH, Xu JJ. Benefit of everolimus in treatment of an intrahepatic cholangiocarcinoma patient with a PIK3CA mutation. World J Gastroenterol 2017; 23(23): 4311-4316

Received	2017-02-27 09:42
Peer-Review Started	2017-02-27 11:03
To Make the First Decision	2017-04-10 14:42
Return for Revision	2017-04-11 14:45
Revised	2017-04-22 17:47
Second Decision	2017-05-18 03:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-05-19 08:01
Articles in Press	2017-05-19 08:01
Publication Fee Transferred	2017-05-24 06:30
Edit the Manuscript by Language Editor	2017-05-27 07:01
Typeset the Manuscript	2017-06-09 09:28

ISSN	1007-9327 (print) and 2219-2840 (online)
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