Publication Name	World Journal of Methodology
Manuscript ID	33887
Country	Australia

Category	Medical Laboratory Technology
Manuscript Type	Review
Article Title	Shortness of breath in clinical practice: A case for left atrial function and exercise stress testing for a comprehensive diastolic heart failure workup
Manuscript Source	Invited Manuscript
All Author List	Pupalan Iyngkaran, Nagesh S Anavekar, Christopher Neil, Liza Thomas and David L Hare
Funding Agency and Grant Number
Corresponding Author	Pupalan Iyngkaran, FRACP, MBBS, MD, Senior Lecturer, Department of Medicine, Northern Territory Medical School, Flinders University, Charles Darwin University campus, Yellow Building 4 Cnr University Drive North and University Drive West, Casuarina NT 0815, Australia. pupalan.iyngkaran@flinders.edu.au
Key Words	Diastolic heart failure; Exercise stress test; Left atrium; Shortness of breath; Work-up
Core Tip	Shortness of breath is a common clinical complaint. Etiologies such as systolic heart failure, obstructive airways disease or anemia have clear and reproducible physiological changes detectable through routine diagnostic tests. Diastolic heart failure (DHF) is often a diagnosis of exclusion. In the absence of directly demonstrating an elevation of left ventricular end diastolic pressures at rest or exercise, DHF is inferred by a combination of symptoms and resting echocardiography findings. We discuss the importance of a wider con¬sideration, e.g., left atrium function and exercise stress testing, in DHF work-up.
Citation	Iyngkaran P, Anavekar NS, Neil C, Thomas L, Hare DL. Shortness of breath in clinical practice: A case for left atrial function and exercise stress testing for a comprehensive diastolic heart failure workup. World J Methodol 2017; 7(4): 117-128

Received	2017-03-10 13:52
Peer-Review Started	2017-03-17 16:04
To Make the First Decision	2017-05-23 00:52
Return for Revision	2017-06-12 04:25
Revised	2017-08-16 05:31
Second Decision	2017-11-14 11:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-11-22 19:03
Articles in Press	2017-11-22 19:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-12-22 03:58

ISSN	2222-0682 (online)
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