Publication Name	World Journal of Cardiology
Manuscript ID	33910
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Is Entresto good for the brain?
Manuscript Source	Unsolicited Manuscript
All Author List	Nirav Patel and Jason Gluck
Funding Agency and Grant Number
Corresponding Author	Nirav Patel, MD, Department of Cardiology, University of Connecticut, Harford Hospital, 80 Seymour Street, Hartford, CT 06102, United States. nirav.patel@hhchealth.org
Key Words	Heart failure; Sacubitril-valsartan; Entresto; LCZ696; Neprilysin inhibitor; Alzheimer’s disease
Core Tip	We are discussing an innovative and exciting new treatment for heart failure (HF). This advance in pharmacotherapy has shown promising results and is rapidly incorporating into standard medical therapy for HF. There is, however, a theoretical concern for cognitive dysfunction and early onset Alzheimer’s disease particularly in the young. This review informs clinicians of the mechanism and potential for cognitive dysfunction, thereby increasing awareness and promoting informed prescribing.
Citation	Patel N, Gluck J. Is Entresto good for the brain? World J Cardiol 2017; 9(7): 594-599

Received	2017-03-14 09:46
Peer-Review Started	2017-03-14 16:13
To Make the First Decision	2017-04-14 10:34
Return for Revision	2017-04-20 09:44
Revised	2017-05-16 17:39
Second Decision	2017-05-19 11:17
Accepted by Journal Editor-in-Chief	2017-05-19 21:34
Accepted by Company Editor-in-Chief	2017-05-24 00:55
Articles in Press	2017-05-24 00:55
Publication Fee Transferred	2017-05-24 02:19
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-07-11 07:24

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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