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9/13/2017 7:31:01 PM | Browse: 151 | Download: 239
Publication Name World Journal of Stem Cells
Manuscript ID 34298
Country/Territory Japan
Category Cell Biology
Manuscript Type Basic Study
Article Title Aldehyde dehydrogenase activity helps identify a subpopulation of murine adipose-derived stem cells with enhanced adipogenic and osteogenic differentiation potential
Manuscript Source Unsolicited Manuscript
All Author List Harumichi Itoh, Shimpei Nishikawa, Tomoya Haraguchi, Yu Arikawa, Shotaro Eto, Masato Hiyama, Toshie Iseri, Yoshiki Itoh, Munekazu Nakaichi, Yusuke Sakai, Kenji Tani, Yasuho Taura and Kazuhito Itamoto
Funding Agency and Grant Number
Funding Agency Grant Number
JSPS KAKENHI (Grants-in-Aid for Scientific Research; grant No. 26893172) to Nishikawa S
Corresponding Author Shimpei Nishikawa, PhD, Department of Small Animal Clinical Science, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8511, Japan. sn2007@yamaguchi-u.ac.jp
Key Words Adipose-derived stem/stromal cell; Aldehyde dehydrogenase activity; Flow cytometry; Subpopulation; Ribosome
Core Tip Aldehyde dehydrogenase (ALDH) activity is widely used as a stem cell marker in several types of normal or malignant tissues. However, there was no report of ALDH activity in murine adipose-derived stem cells (ADSCs). Here, our study demonstrated a subpopulation defined by high ALDH activity within murine ADSCs. The subpopulation with high ALDH activity (ALDHHi) showed enhanced differentiation potentials into adipocyte and osteocyte. Furthermore, gene set enrichment analysis revealed that ribosome-related gene sets were enriched in ALDHHi of murine ADSCs. We showed relationship between ALDHHi and ribosome biosynthesis, providing a novel insight of mesenchymal stem cell biology.
Citation Itoh H, Nishikawa S, Haraguchi T, Arikawa Y, Eto S, Hiyama M, Iseri T, Itoh Y, Nakaichi M, Sakai Y, Tani K, Taura Y, Itamoto K. Aldehyde dehydrogenase activity helps identify a subpopulation of murine adipose-derived stem cells with enhanced adipogenic and osteogenic differentiation potential. World J Stem Cells 2017; 9(10): 179-186
Received
2017-04-24 09:35
Peer-Review Started
2017-04-26 08:37
To Make the First Decision
2017-05-23 00:47
Return for Revision
2017-05-23 09:30
Revised
2017-07-11 00:34
Second Decision
2017-09-06 08:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-09-13 19:31
Articles in Press
2017-09-13 19:31
Publication Fee Transferred
2017-10-04 08:49
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-10-23 07:18
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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