Publication Name	World Journal of Hepatology
Manuscript ID	34331
Country	Japan

Category	Oncology
Manuscript Type	Case Report
Article Title	Primary biliary cholangitis metachronously complicated with combined hepatocellular carcinomacholangiocellular carcinoma and hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Ryuta Ide, Akihiko Oshita, Takashi Nishisaka, Hideki Nakahara, Shiomi Aimitsu and Toshiyuki Itamoto
Funding Agency and Grant Number
Corresponding Author	Akihiko Oshita, MD, PhD, Surgeon, Department of Gastroenterological Surgery, Hiroshima Prefectural Hospital, 1-5-54 Ujina-kanda, Minami-ku, Hiroshima 734-8530, Japan. oshita-akihiko@umin.ac.jp
Key Words	Primary biliary cholangitis; Combined hepatocellular carcinoma and cholangiocellular carcinoma; Hepatocellular carcinoma
Core Tip	Primary biliary cholangitis (PBC) is a progressive cholestatic liver disease characterized by the presence of highly specific antimitochondrial antibodies, portal inflammation and lymphocyte-dominated destruction of the intrahepatic bile ducts, which leads to cirrhosis. While its pathogenesis remains unclear, PBC that shows histological progression to fibrosis carries a high risk of carcinogenesis; the same is true of viral liver diseases. In patients with PBC, the development of hepatocellular carcinoma is rare; the development of combined hepatocellular carcinoma and cholangiocellular carcinoma (cHCC-CCC) is extraordinary. Herein, we report a rare case of PBC metachronously complicated by cHCC-CCC and HCC; which, to the best of our knowledge, has never been reported.
Citation	Ide R, Oshita A, Nishisaka T, Nakahara H, Aimitsu S, Itamoto T. Primary biliary cholangitis metachronously complicated with combined hepatocellular carcinoma-cholangiocellular carcinoma and hepatocellular carcinoma. World J Hepatol 2017; 9(36): 1378-1384 Available from: URL: http://www.wjgnet.com/1948-5182/full/v9/i36/1378.htm DOI: http://dx.doi.org/10.4254/wjh.v9.i36.1378

Received	2017-06-19 00:45
Peer-Review Started	2017-06-19 07:25
To Make the First Decision	2017-07-10 00:50
Return for Revision	2017-07-20 07:54
Revised	2017-10-15 13:12
Second Decision	2017-11-14 11:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-11-20 06:48
Articles in Press	2017-11-20 06:48
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-11-29 18:35
Typeset the Manuscript	2017-12-26 01:02

ISSN	1948-5182 (online)
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