Publication Name	World Journal of Clinical Cases
Manuscript ID	34667
Country	Switzerland

Category	Medicine, Research & Experimental
Manuscript Type	Case Report
Article Title	Do you want to participate in a clinical study as a healthy control? - Risk or benefit?
Manuscript Source	Unsolicited Manuscript
All Author List	Hanna Giessen, Christian A Nebiker, Matthias Bruehlmeier, Stefan Spreitzer, Beat Mueller and Philipp Schuetz
Funding Agency and Grant Number
Corresponding Author	Philipp Schuetz, MD, Professor, Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse 1, Aarau 5000, Switzerland. philipp.schuetz@ksa.ch
Key Words	Medullary thyroid cancer; Procalcitonin; Thyroid nodes; Endocrinology; Public health; Healthy control
Core Tip	A lady participating as healthy control in a study was found to suffer from a medullary thyroid cancer, a type of cancer in total surgical removal before the tumor has spread is the most important prognostic factor. The difficulty is the low diagnostic accuracy of ultrasound and procalcitonin-computed tomography scan, as well as the limitations of fine needle aspiration in a patient with several nodules. This case illustrates the consequences of volunteering as a “healthy control” in a clinical study. While early detection of the MCT was possible in our patient it paid off for her, but abnormal test results may also cause harm to patients if being false positive and leading to invasive procedures.
Citation	Giessen H, Nebiker CA, Bruehlmeier M, Spreitzer S, Mueller B, Schuetz P. Do you want to participate in a clinical study as a healthy control? - Risk or benefit? World J Clin Cases 2017; 5(12): 437-439

Received	2017-05-15 01:36
Peer-Review Started	2017-05-17 07:17
To Make the First Decision	2017-06-14 00:47
Return for Revision	2017-06-16 06:03
Revised	2017-10-26 03:23
Second Decision	2017-11-06 08:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-11-10 18:33
Articles in Press	2017-11-10 18:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-12-06 07:10

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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