Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	34856
Country	Greece

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Association of miR-146 rs2910164, miR-196a rs11614913, miR-221 rs113054794 and miR-224 rs188519172 polymorphisms with anti-TNF treatment response in a Greek population with Crohn’s disease
Manuscript Source	Invited Manuscript
All Author List	Ioannis Papaconstantinou, Christina Kapizioni, Evangelia Legaki, Elena Xourgia, George Karamanolis, Antonios Gklavas and Maria Gazouli
Funding Agency and Grant Number
Corresponding Author	Maria Gazouli, Associate Professor, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Michalakopoulou 176, Athens 11527, Greece. mgazouli@med.uoa.gr
Key Words	MicroRNA; Crohn’s disease; Polymorphisms; Anti-TNF; Biomarkers
Core Tip	Anti-TNF agents are the cornerstone of inflammatory bowel disease (IBD) treatment strategy so far though not effective in one third of patients in the first months of administration. Biomarkers for prediction of each patient’s treatment response are vigorously sought in the era of personalized medicine. MicroRNAs have been studied as possible predictors of response to therapy in cancer and autoimmune diseases including IBD. MiRNA polymorphisms though have never been studied in IBD as markers of anti-TNF response. Our results suggest that for rs2910164, rs11614913, rs113054794, and rs188519172 no association to anti-TNF agents’ response in patients with Crohn’s disease can be established.
Citation	Papaconstantinou I, Kapizioni C, Legaki E, Xourgia E, Kara¬manolis G, Gklavas A, Gazouli M. Association of miR-146 rs2910164, miR-196a rs11614913, miR-221 rs113054794 and miR-224 rs188519172 polymorphisms with anti-TNF treatment response in a Greek population with Crohn’s disease. World J Gastrointest Pharmacol Ther 2017; 8(4): 193-200

Received	2017-06-08 01:17
Peer-Review Started	2017-06-08 07:33
To Make the First Decision	2017-08-08 01:09
Return for Revision	2017-08-08 08:03
Revised	2017-08-21 08:18
Second Decision	2017-09-08 09:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-09-15 00:35
Articles in Press	2017-09-15 00:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-10-31 03:56

ISSN	2150-5349 (online)
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