Publication Name	World Journal of Gastroenterology
Manuscript ID	34921
Country	Japan

Category	Oncology
Manuscript Type	Basic Study
Article Title	Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis
Manuscript Source	Unsolicited Manuscript
All Author List	Akiharu Kimura, Kyoichi Ogata, Bolag Altan, Takehiko Yokobori, Erito Mochiki, Mitsuhiro Yanai, Norimichi Kogure, Toru Yanoma, Masaki Suzuki, Tuya Bai and Hiroyuki Kuwano
Funding Agency and Grant Number
Corresponding Author	Akiharu Kimura, MD, PhD, Senior Lecturer, Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan. akimura@gunma-u.ac.jp
Key Words	Peritoneal metastasis; Hyperthermia; Hyperthermo-chemotherapy; Heat shock protein 110; Gastric cancer; Drug resistance
Core Tip	Gastric cancer remains one of the most common cancers worldwide. Peritoneal dissemination is the most common reason behind gastric cancer (GC) recurrence, and the median survival duration for patients with metastatic and recurrent GC is only 13–16 mo. In our department, we have used intraperitoneal hyperthermo-chemotherapy in patients with advanced rectal cancer and GC with peritoneal metastasis. In this study, we evaluated the significance of heat shock protein 110 (HSP110) expression in GC patients with peritoneal metastasis and assessed the effects of HSP110 suppression on hyperthermo-chemotherapy sensitivity in vitro.
Citation	Kimura A, Ogata K, Altan B, Yokobori T, Mochiki E, Yanai M, Kogure N, Yanoma T, Suzuki M, Bai T, Kuwano H. Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis. World J Gastroenterol 2017; 23(42): 7541-7550

Received	2017-06-29 01:17
Peer-Review Started	2017-06-30 08:38
To Make the First Decision	2017-07-27 07:56
Return for Revision	2017-08-01 11:25
Revised	2017-09-08 15:59
Second Decision	2017-09-15 00:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-09-19 21:01
Articles in Press	2017-09-19 21:01
Publication Fee Transferred	2017-09-27 12:40
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-11-06 04:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com