Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	35175
Country	United States

Category	Oncology
Manuscript Type	Minireviews
Article Title	Neoadjuvant therapy for resectable pancreatic cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Sheikh Hasibur Rahman, Robin Urquhart and Michele Molinari
Funding Agency and Grant Number
Corresponding Author	Michele Molinari, MD, MSc, Senior Scientist, Surgeon, Department of Surgery, University of Pittsburgh Medical Center, 3459 Fifth Avenue, N758, Pittsburgh, PA 15213, United States. molinarim@upmc.edu
Key Words	Pancreatic adenocarcinoma; Neoadjuvant chemotherapy; Neoadjuvant chemoradiation therapy; Meta-analysis; Decision analysis; Borderline resectable; Locally advanced; Randomized controlled trial; Phase Ⅰ trial; Phase Ⅱ trial; Phase Ⅲ trial
Core Tip	The use of neoadjuvant therapy for patients with resectable pancreatic cancer (PC) has been used by an increasing number of cancer centers around the world. The main rationale of using neoadjuvant therapies in resectable PC is the hope that patients’ likelihood of long-term overall survival will benefit from the chemo or chemoradiation therapy administered when their overall conditions allow them to tolerate the treatment. At this time, there is no phase Ⅲ trial to support the use of neoadjuvant therapies in resectable PC. Without strong scientific evidence supporting the theoretical advantages of neoadjuvant therapies, these potential benefits might turn out not to be worth the risk of tumors progression while waiting for surgery.
Citation	Rahman SH, Urquhart R, Molinari M. Neoadjuvant therapy for resectable pancreatic cancer. World J Gastrointest Oncol 2017; 9(12): 457-465

Received	2017-06-26 01:48
Peer-Review Started	2017-06-27 08:59
To Make the First Decision	2017-08-07 01:03
Return for Revision	2017-08-07 02:38
Revised	2017-08-24 14:24
Second Decision	2017-09-06 08:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-09-16 19:03
Articles in Press	2017-09-16 19:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-12-08 03:05

ISSN	1948-5204 (online)
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