Publication Name	World Journal of Gastroenterology
Manuscript ID	35229
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Efficacy of postoperative adjuvant transcatheter arterial chemoembolization in hepatocellular carcinoma patients with microvascular invasion
Manuscript Source	Unsolicited Manuscript
All Author List	Jia-Zhou Ye, Jun-Ze Chen, Zi-Hui Li, Tao Bai, Jie Chen, Shao-Liang Zhu, Le-Qun Li and Fei-Xiang Wu
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Guangxi 2012GXNSFAA053162 Key project of Guangxi Health and Family Planning Commission, China S201513 Key Project of Guangxi Science and Technology Department, China Gui Ke AB16380242
Corresponding Author	Fei-Xiang Wu, MD, Professor, Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, He Di Road No. 71, Nanning 530021, Guangxi Zhuang Autonomous Region, China. wufeixiang@gxmu.edu.cn
Key Words	Hepatocellular carcinoma; Microvascular invasion; Postoperative adjuvant transcatheter arterial chemoembolization; Recurrence-free survival; Overall survival
Core Tip	Microvascular invasion (MVI) is an independent risk factor attributed to frequent tumor recurrence in Barcelona Clinic Liver Cancer (BCLC) early- and intermediate-stage hepatocellular carcinoma (HCC) patients. Postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE) has been confirmed to be effective in suppressing early recurrence and delaying the progression of recurrent tumors, thereby improving the overall survival (OS) in HCC patients with macrovascular invasion. However, whether PA-TACE could provide the survival benefit to HCC patients with MVI remains unclear. The present study showed that PA-TACE is an effective method that can safely suppress the recurrence and improve the survival of BCLC early- and intermediate-stage HCC patients with MVI. However, it failed to provide obvious OS or recurrence-free survival benefits to patients without MVI.
Citation	Ye JZ, Chen JZ, Li ZH, Bai T, Chen J, Zhu SL, Li LQ, Wu FX. Efficacy of postoperative adjuvant transcatheter arterial chemoembolization in hepatocellular carcinoma patients with microvascular invasion. World J Gastroenterol 2017; 23(41): 7415-7424

Received	2017-07-26 01:08
Peer-Review Started	2017-07-26 12:51
To Make the First Decision	2017-08-10 00:28
Return for Revision	2017-08-14 13:32
Revised	2017-09-09 05:26
Second Decision	2017-09-15 00:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-09-19 20:56
Articles in Press	2017-09-19 20:56
Publication Fee Transferred	2017-10-02 14:49
Edit the Manuscript by Language Editor	2017-10-16 13:26
Typeset the Manuscript	2017-10-31 03:50

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com