Publication Name	World Journal of Gastroenterology
Manuscript ID	35260
Country	Finland

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Faecal microbiota transplantation in patients with Clostridium difficile and significant comorbidities as well as in patients with new indications: A case series
Manuscript Source	Unsolicited Manuscript
All Author List	Perttu Lahtinen, Eero Mattila, Veli-Jukka Anttila, Jyrki Tillonen, Matti Teittinen, Pasi Nevalainen, Seppo Salminen, Reetta Satokari and Perttu Arkkila
Funding Agency and Grant Number
Corresponding Author	Perttu Lahtinen, MD, Department of Gastroenterology, Päijät-Häme Central Hospital, Keskussairaalankatu 7, Lahti 15610, Finland. perttupaavali@gmail.com
Key Words	Faecal microbiota transplantation; Antibiotic resistance; Clostridium difficile infection; Microbiota; Immunodeficiency; Salmonella infection
Core Tip	Knowledge of faecal microbiota transplantation (FMT) in immunocompromised patients and patients with conditions other than recurrent Clostridium difficile infection (rCDI) is scarce. We reviewed 13 FMT-treated patients with rCDI and major comorbidities as well as 8 patients with new indications. In our cohort, FMT appeared to be safe and effective for immuno­compromised patients: dialysis patients, human immu­nodeficiency virus patients, solid organ trans­plant patients and a patient with chronic lymphatic leuka­emia. Of the patients treated for indications other than rCDI, the most promising results were successful eradication of antibiotic-resistant bacteria. Eradication of chronic Salmonella carriage in two patients with FMT represents the first cases reported to date.
Citation	Lahtinen P, Mattila E, Anttila VJ, Tillonen J, Teittinen M, Nevalainen P, Salminen S, Satokari R, Arkkila P. Faecal microbiota transplantation in patients with Clostridium difficile and significant comorbidities as well as in patients with new indications: A case series. World J Gastroenterol 2017; 23(39): 7174-7184

Received	2017-07-31 00:19
Peer-Review Started	2017-07-31 00:59
To Make the First Decision	2017-08-15 03:40
Return for Revision	2017-08-16 09:27
Revised	2017-09-08 11:23
Second Decision	2017-09-15 00:06
Accepted by Journal Editor-in-Chief	2017-09-15 16:06
Accepted by Company Editor-in-Chief	2017-09-19 20:53
Articles in Press	2017-09-19 20:53
Publication Fee Transferred	2017-09-21 06:29
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-10-18 03:03

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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