Publication Name	World Journal of Gastroenterology
Manuscript ID	35483
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Astragaloside IV inhibits pathological functions of gastric cancer-associated fibroblasts
Manuscript Source	Unsolicited Manuscript
All Author List	Zhen-Fei Wang, Da-Guang Ma, Zhe Zhu, Yong-Ping Mu, Yong-Yan Yang, Li Feng, Hao Yang, Jun-Qing Liang, Yong-Yan Liu, Li Liu and Hai-Wen Lu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81760552 Program of the Inner Mongolia Natural Science Foundation 2016MS0824 Program of the Inner Mongolia Natural Science Foundation 2015MS0896 Program of “Keji Baiwan Gongcheng” of Inner Mongolia Medical University YKD2015KJBW008 Supporting Program for Outstanding Youth in Science and Technology of Inner Mongolia Autonomous Region NJYT-17-B30
Corresponding Author	Hai-Wen Lu, PhD, Professor, The Laboratory for Tumor Molecular Diagnosis, Affiliated People’s Hospital of Inner Mongolia Medical University, 42 Zhaowuda, Huhhot 010021, Inner Mongolia Autonomous Region, China. haiwen_l@yeah.net
Key Words	Astragaloside IV; Gastric cancer-associated fibroblasts; Proliferation; Migration; Invasion; MicroRNA
Core Tip	Most of the chemotherapeutic agents directly act on cancer cells. However, direct drug attacks on cancer cells have the drawbacks of accelerating cancer evolution, chemoresistance, recurrence and metastasis. Cancer-associated fibroblasts considerably contribute to cancer initiation and progression by providing nourishment and support for cancer cells. Blocking the pathological functions of cancer-associated fibroblasts can eliminate the conditions suitable for cancer cell survival and expansion, representing a novel effective anti-cancer strategy. Unfortunately, few effective drugs have been found against cancer-associated fibroblasts. Here, Astragaloside IV significantly inhibited the pathological functions of gastric cancer-associated fibroblast, suggesting its valuable therapeutic application for gastric carcinoma.
Citation	Wang ZF, Ma DG, Zhu Z, Mu YP, Yang YY, Feng L, Yang H, Liang JQ, Liu YY, Liu L, Lu HW. Astragaloside Ⅳ inhibits pathological functions of gastric cancer-associated fibroblasts. World J Gastroenterol 2017; 23(48): 8512-8525

Received	2017-07-25 14:16
Peer-Review Started	2017-07-25 21:17
To Make the First Decision	2017-09-15 01:31
Return for Revision	2017-09-17 18:50
Revised	2017-09-29 14:32
Second Decision	2017-11-21 10:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-11-21 18:55
Articles in Press	2017-11-21 18:55
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-12-04 01:25
Typeset the Manuscript	2017-12-21 03:51

ISSN	1007-9327 (print) and 2219-2840 (online)
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