Publication Name	World Journal of Gastroenterology
Manuscript ID	35931
Country	Portugal

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Endoscopic balloon dilation of Crohn’s disease strictures-safety, efficacy and clinical impact
Manuscript Source	Unsolicited Manuscript
All Author List	Susana Lopes, Eduardo Rodrigues-Pinto, Patrícia Andrade, Joana Afonso, Todd H Baron, Fernando Magro and Guilherme Macedo
Funding Agency and Grant Number
Corresponding Author	Guilherme Macedo, MD, PhD, Chief Doctor, Gastroenterology, Macedo, G (reprint author), Hosp Sao Joao, Fac Med, Dept Gastroenterol, Oporto, Portugal., Alameda Professor Hêrnani Monteiro, Porto 4200-319, Portugal. guilhermemacedo59@gmail.com
Key Words	Crohn's disease; Endoscopic recurrence; Anastomotic strictures; Non-anastomotic strictures; Endoscopic balloon dilation
Core Tip	This study evaluated the incidence of anastomotic strictures after intestinal resection in Crohn's disease (CD), the long-term efficacy and safety of endoscopic balloon dilation (EBD) in CD strictures and its impact on the diagnosis of subclinical postoperative endoscopic recurrence. Almost one-third of CD patients developed an anastomotic stricture after ileocecal resection/right hemicolectomy. EBD was an effective and safe alternative to surgery, with a good short and long-term outcome, postponing or even avoiding further surgery. EBD also allowed to diagnose disease recurrence in patients with no clinical signs/biomarkers of disease activity. Longer intervals after surgery and higher lactoferrin levels were associated with anastomotic strictures; time until dilation was lower in patients with calprotectin levels > 83.35 µg/g and current/past history of smoking.
Citation	Lopes S, Rodrigues-Pinto E, Andrade P, Afonso J, Baron TH, Magro F, Macedo G. Endoscopic balloon dilation of Crohn’s disease strictures-safety, efficacy and clinical impact. World J Gastroenterol 2017; 23(41): 7397-7406

Received	2017-08-18 00:36
Peer-Review Started	2017-08-19 04:21
To Make the First Decision	2017-08-30 00:04
Return for Revision	2017-09-04 08:31
Revised	2017-09-11 13:59
Second Decision	2017-09-13 04:08
Accepted by Journal Editor-in-Chief	2017-09-13 15:23
Accepted by Company Editor-in-Chief	2017-09-19 20:45
Articles in Press	2017-09-19 20:45
Publication Fee Transferred	2017-09-29 05:40
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-10-23 06:30

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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